SPECIFICITY OF PASSIVE SERUM PROTECTION AGAINST NIPPOSTRONGYLUS-BRASILIENSIS AND NEMATOSPIROIDES-DUBIUS IN MICE
SPECIFICITY OF PASSIVE SERUM PROTECTION AGAINST NIPPOSTRONGYLUS-BRASILIENSIS AND NEMATOSPIROIDES-DUBIUS IN MICE
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DOI：
10.1038/icb.1983.4
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
DOBSON, C
中科院分区：
文献类型：
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作者：
BRINDLEY, PJ;DOBSON, C
小鼠注射抗N. brasiliensis或N.与对照小鼠相比，感染同源线虫后的小鼠。保护性免疫的被动转移对于在供体小鼠中诱导抗体应答的种属是特异性的。感染异源线虫的被动免疫小鼠与对照小鼠中的寄生虫具有相同数量的蠕虫，具有相同的卵输出，但它们发育迟缓。2份供体抗血清池与N. Alcohus和N.巴西人抗原
Fewer and smaller worms were recovered from, and significantly fewer parasite eggs were voided by, mice injected with mouse antiserum raised against N. brasiliensis or N. dubius after infection with the homologous nematode species compared with the control mice. The passive transfer of protective immunity was specific for the species which induced the antibody response in the donor mice. Passively immunized mice infected with the heterologous nematode species harbored the same number of worms, with the same egg output, as parasites in the control mice, but they were stunted. Serological cross-reactions were observed between the 2 donor antiserum pools and N. dubius and N. brasiliensis antigens.