Risk factors for age related maculopathy in a Japanese population: the Hisayama study
Risk factors for age related maculopathy in a Japanese population: the Hisayama study
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DOI：
10.1136/bjo.87.4.469
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发表时间：
2003-04-01
影响因子：
4.1
通讯作者：
Nose, Y
中科院分区：
文献类型：
--
作者：
Miyazaki, M;Nakamura, H;Nose, Y
目的：研究日本人群中年龄相关性黄斑病变（ARM）的危险因素。方法：1998年对久山市居民进行横断面社区调查。共有596名男性和886名女性同意参加这项研究，他们居住在日本久山市，年龄在50岁或以上。每位参与者都接受了包括眼科检查在内的全面检查。通过间接眼底检查、裂隙灯检查和眼底彩色照片的分级来确定ARM的存在。使用这些横截面数据，进行逻辑回归分析以确定ARM的危险因素。使用以下10个可能的危险因素：年龄、白内障、高血压（病史）、高血压（病史或检查）、糖尿病、高脂血症、当前吸烟者、酒精摄入量、BMI和白细胞。结果：男性检出率为19.5%，女性为14.9%。研究发现，男性患ARM的比例明显高于女性。多元logistic回归分析显示，年龄和高血压（病史或检查）与男性的ARM显著相关，而只有年龄是女性ARM的显著危险因素。结论：本研究提示年龄和男性是日本发生ARM的相关危险因素。此外，高血压也是男性的一个相关危险因素。
Aims: To examine the risk factors for age related maculopathy (ARM) in a sample Japanese population.Methods: In 1998, a cross sectional community survey was conducted among residents of Hisayama. A total of 596 men and 886 women living in Hisayama, Japan, aged 50 years or older consented to participate in the study. Each participant underwent a comprehensive examination that included an ophthalmic examination. The presence of ARM was determined by grading from fundus examination by indirect ophthalmoscopy, slit lamp examination, and colour fundus photographs. Using these cross sectional data, logistic regression analyses were performed to determine the risk factors for ARM. The following 10 possible risk factors were used: age, cataract, hypertension (history), hypertension (history or examination), diabetes, hyperlipidaemia, current smoker, alcohol intake, BMI, and WBC.Results: ARM was detected in 19.5% of men and 14.9% of women. Men were found to have a significantly higher prevalence of ARM than women. Multiple logistic regression analysis showed that age and hypertension (history or examination) were significantly associated with ARM in men, whereas only age was a significant risk factor for ARM in women.Conclusions: This study suggests that higher age and male sex are relevant risk factors for ARM in Japan. In addition, hypertension is a relevant risk factor in men.