Oxidative-Species-Selective Materials for Diagnostic and Therapeutic Applications
Oxidative-Species-Selective Materials for Diagnostic and Therapeutic Applications
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用于诊断和治疗应用的氧化物质选择性材料
DOI：
10.1002/anie.201915833
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Song Jibin
中科院分区：
文献类型：
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作者：
Zhao Caiyan;Chen Jingxiao;Zhong Ruibo;Chen Dean Shuailin;Shi Jinjun;Song Jibin
随着人们越来越认识到氧化物质在许多疾病发病机制中的不同作用和重要性，已经进行了大量关于开发氧化物质响应材料的工作，用于1）检测氧代谢物或诊断氧化应激相关疾病，2）减少疾病部位的氧化应激，和/或3）递送治疗和诊断剂。 在这篇综述中，我们首先讨论了不同的特点和生物学功能的氧化物种。然后系统地阐明化学接头/基团对特定氧化物种的选择性和敏感性以及其特定相互作用的基本化学。还强调了它们潜在的生物医学应用。我们期望这一全面的综述将为氧化物种选择性材料的设计和开发提供更多的见解，以实现更有效的诊断和治疗应用。
With the increasing recognition of the diverse roles and significance of oxidative species in the pathogenesis of many diseases, a tremendous amount of work on the development of oxidative‐species‐responsive materials has been conducted for 1) detecting oxygen metabolites or diagnosis of oxidative‐stress‐relevant diseases, 2) reducing oxidative stress in the disease sites, and/or 3) delivering therapeutic and diagnostic agents. In this review, we first discuss the distinct features and biological functions of each oxidative species. Then the selectivity and sensitivity of chemical linkers/groups to specific oxidative species and the underlying chemistry of their particular interactions are systematically elucidated. Their potential biomedical applications are also highlighted. We expect that this comprehensive review will provide more insights for the design and development of oxidative‐species‐selective materials for more effective diagnostic and therapeutic applications.