Hairless is a nuclear receptor corepressor essential for skin function.
Hairless is a nuclear receptor corepressor essential for skin function.
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DOI：
10.1621/nrs.07010
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发表时间：
2009-12-31
期刊：
影响因子：
--
通讯作者：
Thompson CC
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文献类型：
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作者：
Thompson CC
核受体的活性受到许多共调节因子的调节。辅阻遏物可以介导核受体抑制转录的能力，或者可以抑制核受体的反式激活。随着我们对转录抑制机制的了解越来越多，核受体在发育和疾病中的抑制作用的重要性变得越来越清楚。由哺乳动物无毛（Hr）基因编码的蛋白质被证明是一个辅阻遏物，凭借其功能相似的完善的辅阻遏物N-CoR和SMRT。Hr基因的突变导致小鼠和人的先天性脱发。在体外和小鼠模型中对无毛功能的研究揭示了通过调节上皮干细胞的分化在维持皮肤和毛发中的关键作用，以及通过染色质重塑在调节基因表达中的假定作用。
The activity of nuclear receptors is modulated by numerous coregulatory factors. Corepressors can either mediate the ability of nuclear receptors to repress transcription, or can inhibit transactivation by nuclear receptors. As we learn more about the mechanisms of transcriptional repression, the importance of repression by nuclear receptors in development and disease has become clear. The protein encoded by the mammalian Hairless (Hr) gene was shown to be a corepressor by virtue of its functional similarity to the well-established corepressors N-CoR and SMRT. Mutation of the Hr gene results in congenital hair loss in both mice and men. Investigation of Hairless function both in vitro and in mouse models in vivo has revealed a critical role in maintaining skin and hair by regulating the differentiation of epithelial stem cells, as well as a putative role in regulating gene expression via chromatin remodeling.