Postnatal clinical and imaging follow-up of infants with prenatal isolated mild ventriculomegaly: a series of 101 cases
Postnatal clinical and imaging follow-up of infants with prenatal isolated mild ventriculomegaly: a series of 101 cases
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DOI：
10.1007/s00247-007-0582-2
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发表时间：
2007-10-01
影响因子：
2.3
通讯作者：
Garel, Catherine
中科院分区：
文献类型：
--
作者：
Falip, Celine;Blanc, Nathalie;Garel, Catherine
目的评价大量轻度脑室肿大(IMV)胎儿的出生后临床结局，并将其与出生前和出生后的影像进行对比。材料与方法我们报道了101例IMV胎儿(10-15 mm脑室扩大，超声、MRI、核型和TORCH筛查正常)的前瞻性研究。IMV分为轻度(10~11.9 mm)和中度(12~15 mm)。根据产前超声随访，脑室增大被认为是单侧或双侧的、稳定的、进行性的、退行性的或消失的。临床随访由一名神经儿科医生进行。结果轻度IMV优良率94%，中度IMV优良率85%。单侧和双侧IMV之间，稳定、消退和消退IMV之间无差异，诊断时不受胎龄和性别的影响。在9名婴儿中观察到了固定的神经异常。出生后MRI显示脑白质异常14例，其中6例预后较差。结论轻度IMV预后略好于中度IMV。出生后核磁共振显示，三分之二的婴儿脑白质异常，预后不佳。
Background Postnatal imaging and clinical outcome of fetuses with isolated mild ventriculomegaly (IMV) have never been systematically analysed.Objective To evaluate the postnatal clinical outcomes of a large cohort of fetuses with IMV and to correlate them with pre- and postnatal imaging.Materials and methods We report a prospective study of 101 fetuses with IMV (10-15 mm ventriculomegaly with otherwise normal US, MRI, karyotype and TORCH screening). IMV was divided into minor (10-11.9 mm) and moderate (12-15 mm) ventriculomegaly. Ventriculomegaly was considered uni- or bilateral, stable, progressive, regressive or resolved according to the prenatal US follow-up. Clinical follow-up was performed by a neuropaediatrician. Postnatal imaging included cranial US (n=71) and MRI (n=76).Results The outcome of minor and moderate IMV was excellent in 94% and 85% of infants, respectively. It was not different between uni- and bilateral IMV, and between stable, regressive and resolved IMV, and was independent of gestational age at diagnosis and gender. Fixed neurological abnormalities were observed in nine infants. Postnatal MRI showed white-matter abnormalities in 14 infants, including 6 of the 9 infants with a poor outcome.Conclusion The prognosis was slightly better in minor IMV than in moderate IMV. Postnatal MRI showed white-matter abnormalities in two-thirds of the infants with a poor outcome.