Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat
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DOI：
10.1038/s41398-019-0429-2
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发表时间：
2019-02-11
影响因子：
6.8
通讯作者：
Yu, John-Paul J.
中科院分区：
文献类型：
--
作者：
Barnett, Brian R.;Torres-Velazquez, Maribel;Yu, John-Paul J.
扩散张量成像（DTI）为我们理解广泛的精神疾病的白色物质微观结构和大脑连接提供了显着的见解。虽然DTI和其他弥散加权磁共振成像（MRI）方法已经阐明了轴突的贡献，在许多精神疾病中看到的断开，从这些研究中缺乏的是神经突密度和方向的定量指标，特别是重要的特征，在高突触密度的区域，将捕捉突触的贡献精神疾病状态。在这里，我们报告的应用程序的神经突方向分散和密度成像（NODDI），一种新兴的显微结构成像技术，一种新的Disc1 SV三角洲2大鼠模型的精神疾病，并证明了补充和更具体的指数，发现在NODDI比DTI报告的组织显微结构。我们的研究结果表明，全球和性别特异性的变化，白色物质的微结构的完整性和赤字的神经突密度作为一个后果的Disc1 SV三角洲2遗传变异和突出的应用NODDI和神经突密度和神经突分散的定量措施在精神疾病。
Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a broad spectrum of psychiatric disease. While DTI and other diffusion weighted magnetic resonance imaging (MRI) methods have clarified the axonal contribution to the disconnectivity seen in numerous psychiatric diseases, absent from these studies are quantitative indices of neurite density and orientation that are especially important features in regions of high synaptic density that would capture the synaptic contribution to the psychiatric disease state. Here we report the application of neurite orientation dispersion and density imaging (NODDI), an emerging microstructure imaging technique, to a novel Disc1 sv Delta 2 rat model of psychiatric illness and demonstrate the complementary and more specific indices of tissue microstructure found in NODDI than those reported by DTI. Our results demonstrate global and sex-specific changes in white matter microstructural integrity and deficits in neurite density as a consequence of the Disc1 sv Delta 2 genetic variation and highlight the application of NODDI and quantitative measures of neurite density and neurite dispersion in psychiatric disease.