Ethnic Differences in the Prevalence of Myopia and Ocular Biometry in 10- and 11-Year-Old Children: The Child Heart and Health Study in England (CHASE)
Ethnic Differences in the Prevalence of Myopia and Ocular Biometry in 10- and 11-Year-Old Children: The Child Heart and Health Study in England (CHASE)
复制标题
DOI：
10.1167/iovs.10-5528
复制
发表时间：
2010-12-01
影响因子：
4.4
通讯作者：
Whincup, Peter H.
中科院分区：
文献类型：
--
作者：
Rudnicka, Alicja R.;Owen, Christopher G.;Whincup, Peter H.
目的。在英国，儿童近视患病率的种族差异尚未得到很好的表征。在这项研究中，研究了多种族英国儿童屈光状态和眼部生物测量的种族差异。这是一项针对南亚、非洲加勒比黑人和欧洲白人10岁和11岁学龄儿童的横断面研究。测量每只眼的视力、视野自屈光（无睫状体麻痹）和眼生物测量。近视定义为球面等效屈光度为-0.50 D，单眼或双眼视力不超过20/30。采用logistic回归分析各民族近视患病率差异，采用多元线性回归分析各民族眼生物统计学差异。所有模型都根据年龄、性别和学校内的聚类进行了调整。数据来自1179名儿童。南亚儿童、非洲加勒比黑人儿童和欧洲白人儿童的近视患病率分别为25.2%、10.0%和3.4%。与欧洲白人儿童相比，南亚儿童近视的调整优势比（or）为8.9(95%可信区间[CI] 4.0至19.4)，非洲加勒比黑人儿童近视的调整优势比为3.2（95%可信区间[CI] 1.4至7.2）。近视发病率的种族差异主要是由于不同种族的眼轴长度差异。南亚和加勒比黑人儿童的轴向长度较长（0.44 mm； 95% CI分别为0.30 ~ 0.57 mm和0.30 mm； 95% CI分别为0.16 ~ 0.44 mm）。在同样教育环境下的英国儿童中，南亚儿童的近视率最高，其次是非洲裔加勒比黑人和欧洲白人。四分之一的英国南亚儿童患有近视，这与眼轴长度增加密切相关。（Invest Ophthalmol Vis Sci. 2010;51:6270-6276） DOI:10.1167/iovs.10-5528
PURPOSE. Ethnic differences in childhood prevalence of myopia have not been well characterized in the United Kingdom. In this study, ethnic differences in refractive status and ocular biometry were examined in a multiethnic sample of British children.METHODS. This was a cross-sectional study of 10- and 11-year-old school children of South Asian, black African Caribbean, and white European ethnic origin. Vision, open-field autorefraction (without cycloplegia), and ocular biometry were measured in each eye. Myopia was defined as spherical equivalent refraction of -0.50 D with unaided vision of 20/30 or worse (in one or both eyes). Ethnic differences in the prevalence of myopia were examined by using logistic regression, and multiple linear regression was used for ethnic differences in ocular biometry. All models were adjusted for age, sex, and clustering within school.RESULTS. Data were available for 1179 children. The prevalence of myopia was 25.2%, 10.0%, and 3.4%, respectively, in the South Asian, black African Caribbean, and white European children. Adjusted odds ratios (ORs) of myopia compared with the white European children were 8.9 (95% confidence interval [CI] 4.0 to 19.4) in the South Asian and 3.2 (95% CI, 1.4 to 7.2) in black African Caribbean children. Ethnic differences in the prevalence of myopia were largely accounted for by ethnic differences in axial length. The South Asian and black African Caribbean children had longer axial lengths (0.44 mm; 95% CI, 0.30 to 0.57 mm and 0.30 mm; 95% CI, 0.16 to 0.44 mm, respectively).CONCLUSIONS. Among British children exposed to the same schooling environment, the South Asians had the highest prevalence of myopia, followed by the black African Caribbeans compared with the white Europeans. A quarter of British South Asian children were myopic, which is strongly related to increased axial length. (Invest Ophthalmol Vis Sci. 2010;51:6270-6276) DOI:10.1167/iovs.10-5528