Core Protein of Chondroitin Sulfate Proteoglycan Promotes Neurite Outgrowth from Cultured Neocortical Neurons
Core Protein of Chondroitin Sulfate Proteoglycan Promotes Neurite Outgrowth from Cultured Neocortical Neurons
复制标题
硫酸软骨素蛋白多糖的核心蛋白促进培养的新皮质神经元的神经突生长
DOI：
10.1111/j.1471-4159.1991.tb08207.x
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发表时间：
1991
影响因子：
4.7
通讯作者：
S. Kohsaka
中科院分区：
文献类型：
--
作者：
N. Iijima;A. Oohira;T. Mori;K. Kitabatake;S. Kohsaka
摘要：从大鼠脑中纯化硫酸软骨素蛋白多糖（CS-PG），并检查其对胚胎大鼠新皮质神经元原代培养物中神经突生长的影响。在涂有 CS-PG 的培养孔中，神经突生长增加。还检查了由 CS-PG 制备的核心蛋白和糖胺聚糖 (GAG) 的神经突促进活性。在涂有核心蛋白但未涂有 GAG 的培养孔中观察到该活性。这些结果表明，CS-PG 通过其核心蛋白刺激培养神经元的神经突生长。
Abstract: Chondroitin sulfate proteoglycan (CS‐PG) was purified from rat brain and examined for its effect on neurite outgrowth in primary cultures of embryonic rat neocortical neurons. Neurite outgrowth was increased in culture wells coated with CS‐PG. The core protein and glycosaminoglycan (GAG) prepared from the CS‐PG were also examined for neurite‐promoting activity. The activity was observed in culture wells coated with the core protein but not with GAG. These results suggest that CS‐PG stimulates neurite outgrowth from the cultured neurons via its core protein.
通过固定在细胞外基质上的蛋白聚糖调节细胞基质粘附。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Yamagata,M;Suzuki,S;Akiyama,SK;Yamada,KM;Kimata,K
通讯作者：
Kimata,K