Radioimmunoassay of myelin basic protein in spinal fluid. An index of active demyelination.
Radioimmunoassay of myelin basic protein in spinal fluid. An index of active demyelination.
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脊髓液中髓磷脂碱性蛋白的放射免疫测定。
DOI：
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发表时间：
1976
影响因子：
158.5
通讯作者：
G. Mckhann
中科院分区：
文献类型：
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作者：
Steven R. Cohen;R. Herndon;G. Mckhann
用一种灵敏的放射免疫分析法，可以测量脑脊液中的碱性蛋白，我们研究了303例各种神经系统疾病患者。活动性脱髓鞘疾病患者的碱性蛋白水平较高（每毫升17至100 ng）。此外，与对照人群相比，急性加重期的多发性硬化症患者具有这些高水平，缓慢进展型多发性硬化症患者具有较低水平（6至16 ng/ml），而缓解期患者的水平低于4 ng/ml。因此，该测定似乎是活性脱髓鞘的有用指标。
With a sensitive radioimmunoassay that can measure as little as 2 ng of basic protein in cerebrospinal fluid we studied 303 patients with a variety of neurologic diseases. Patients with active demyelinating diseases had high levels (17 to 100 ng per milliliter) of basic protein. Moreover, patients with multiple sclerosis in acute exacerbation had these high levels, those with slowly progressive multiple sclerosis had lower levels (6 to 16 ng per milliliter), and those in remission had less than 4 ng per milliliter, comparable to the control population. Thus, the assay appears to be a useful index of active demyelination.