A structural view of the COPII vesicle coat
A structural view of the COPII vesicle coat
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DOI：
10.1016/j.sbi.2004.02.002
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发表时间：
2004-04-01
影响因子：
6.8
通讯作者：
Goldberg, J
中科院分区：
文献类型：
--
作者：
Bickford, LC;Mossessova, E;Goldberg, J
在分泌途径的初始阶段，COPII囊泡被协调来自内质网的运输囊泡的出芽。衣壳协调一系列事件，包括膜上的自组装，cargo和SNARE分子的选择，以及膜变形成芽以驱动囊泡裂变。最近的分子水平研究有助于解释酵母copii的三个组成部分——sar1 GTPase、Sec23/24亚复合物和Sec13/31亚复合物是如何结合起来组织这一复杂过程的。
The COPII vesicle coat coordinates the budding of transport vesicles from the endoplasmic reticulum in the initial step of the secretory pathway. The coat orchestrates a sequence of events including self-assembly on the membrane, cargo and SNARE molecule selection, and deformation of the membrane into a bud to drive vesicle fission. Recent molecular-level studies have helped to explain how the three components of yeast COPII-Sar1 GTPase, the Sec23/24 subcomplex and the Sec13/31 subcomplex-combine to organize this complex process.