Diffuse tibiofemoral cartilage change prior to the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative
Diffuse tibiofemoral cartilage change prior to the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative
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加速膝骨关节炎发生前的弥漫性胫股软骨变化：来自骨关节炎倡议的数据
DOI：
10.1016/j.joca.2019.02.737
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发表时间：
2019
影响因子：
7
通讯作者：
Liu, S.-H.
中科院分区：
文献类型：
--
作者：
Harkey, M.;Davis, J.;Lu, B.;Price, L.;Eaton, C.;Lo, G.;Barbe, M.;Ward, R.;Zhang, M.;Liu, S.-H.
我们比较了加速型膝关节骨关节炎（KOA）患者与影像学KOA发生前典型KOA患者之间胫股软骨变化的空间分布。我们对来自骨关节炎倡议的129名个体进行了纵向病例对照分析。我们评估了加速型KOA（n =44）与典型KOA（n = 40）发生前2 - 1年36个信息位置的磁共振图像上胫股软骨的百分比变化。我们根据无KOA组（n =45）的软骨百分比变化阈值，在36个信息位置定义了加速和典型KOA组的软骨变化。我们描述了加速KOA和典型KOA组中软骨变化的空间模式，并进行了逻辑回归，以确定弥漫性软骨变化（预测因子;至少一半的胫股区域显示多个信息位置的变化）是否与KOA组（结局）相关。与发生典型膝关节OA的个体相比，具有弥漫性胫股软骨变化的个体发生加速膝关节OA的可能性高2.2倍，这一趋势不显著（OR [95% CI] = 2.2 [0.90-5.14]）。成人加速或典型的KOA表现出异质性的空间分布的软骨变薄和增厚。这些结果提供了初步的证据，不同的空间模式之间的软骨变化的个人谁将发展加速与典型的KOA。这些数据表明，可能有不同的机制驱动加速与典型KOA之间的早期结构性疾病进展。临床解剖学32：369-378，2019年。© 2018威利期刊股份有限公司
We compared the spatial distribution of tibiofemoral cartilage change between individuals who will develop accelerated knee osteoarthritis (KOA) versus typical onset of KOA prior to the development of radiographic KOA. We conducted a longitudinal case–control analysis of 129 individuals from the Osteoarthritis Initiative. We assessed the percent change in tibiofemoral cartilage on magnetic resonance images at 36 informative locations from 2 to 1 year prior to the development of accelerated (n =44) versus typical KOA (n =40). We defined cartilage change in the accelerated and typical KOA groups at 36 informative locations based on thresholds of cartilage percent change in a no KOA group (n =45). We described the spatial patterns of cartilage change in the accelerated KOA and typical KOA groups and performed a logistic regression to determine if diffuse cartilage change (predictor; at least half of the tibiofemoral regions demonstrating change in multiple informative locations) was associated with KOA group (outcome). There was a non‐significant trend that individuals with diffuse tibiofemoral cartilage change were 2.2 times more likely to develop accelerated knee OA when compared with individuals who develop typical knee OA (OR [95% CI] = 2.2 [0.90–5.14]. Adults with accelerated or typical KOA demonstrate heterogeneity in spatial distribution of cartilage thinning and thickening. These results provide preliminary evidence of a different spatial pattern of cartilage change between individuals who will develop accelerated versus typical KOA. These data suggest there may be different mechanisms driving the early structural disease progression between accelerated versus typical KOA. Clin. Anat. 32:369–378, 2019. © 2018 Wiley Periodicals, Inc.