Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.
Aortic endothelial cell replication. I. Effects of age and hypertension in the rat.
复制标题
主动脉内皮细胞复制。
作者：
S. Schwartz;E. Benditt
正常大鼠福尔斯的主动脉内皮细胞每日复制率从出生时的最大值13%下降到5-6个月龄时的0.1-0.3%。这种复制的残余速率在很大程度上代表了正常动物内皮的更新速率。然而，在肾性高血压持续2-3周后，复制率上升10倍，平均值为1.6%。这种增加可能代表周转增加;然而，它可能至少部分代表覆盖扩张血管的扩张管腔表面的增殖反应。
The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the rate of replication rises 10-fold to an average value of 1.6%. This increase may represent an increase in turnover; however, it probably represent, at least in part, a proliferative response to cover the expanded luminal surface of the dilated vessel.