Role and regulation of CD1d in normal and pathological B cells.
Role and regulation of CD1d in normal and pathological B cells.
复制标题
DOI：
10.4049/jimmunol.1401805
复制
发表时间：
2014-11-15
期刊：
影响因子：
--
通讯作者：
Karadimitris A
中科院分区：
文献类型：
--
作者：
Chaudhry MS;Karadimitris A
CD 1d是一种非多态性的MHC I类分子，它将磷酸化和鞘糖脂抗原呈递给称为不变NKT（iNKT）细胞的CD 1d限制性T细胞亚群。这种CD 1d-iNKT细胞轴调节先天性和适应性免疫应答的几乎所有方面。B细胞上CD 1d的表达表明这些细胞能够将抗原呈递给iNKT细胞并与iNKT细胞形成同源相互作用。在此，我们总结了CD 1d在正常B细胞和体液免疫中的作用和调节的关键证据。然后，我们将讨论扩展到B细胞疾病，重点是自身免疫性疾病，病毒感染和肿瘤转化的B谱系细胞，其中CD 1d的表达可以改变作为免疫逃避的机制，可以有诊断和预后的重要性。最后，我们强调了当前和未来的治疗策略，旨在靶向B细胞中的CD 1d-iNKT轴。
CD1d is a non-polymorphic, MHC class I-like molecule, which presents phosphoand glycosphingo-lipid antigens to a subset of CD1d-restricted T cells called invariant NKT (iNKT) cells. This CD1d-iNKT cell axis regulates nearly all aspects of both the innate and adaptive immune response. Expression of CD1d on B cells is suggestive of the ability of these cells to present antigen to and form cognate interactions with iNKT cells. Herein we summarise key evidence regarding the role and regulation of CD1d in normal B cells and in humoral immunity. We then extend the discussion to B cell disorders, with emphasis on autoimmune disease, viral infection and neoplastic transformation of B lineage cells, where CD1d expression can be altered as a mechanism of immune evasion, and can have both diagnostic and prognostic importance. Finally we highlight current and future therapeutic strategies that aim to target the CD1d-iNKT axis in B cells.