Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice.
Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice.
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DOI：
10.1007/s00360-023-01474-9
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发表时间：
2023-03
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--
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当产奶量达到最高时，就会出现泌乳高峰。限制泌乳峰值的因素一直是激烈争论的话题。哺乳高峰期的产奶量似乎受到哺乳期雌性散发加工食品和产奶副产品产生的体热能力的限制。因此，增强散热能力的操作（例如去除皮毛）会增加峰值产奶量。我们研究了实验室小鼠剃毛引起的峰值产奶量增加的潜在相关性。通过乳腺的转录组分析，我们寻找实验性增加产奶量的机制及其对断奶问题上母婴冲突的影响，表现为乳腺退化的提前或延迟。我们证明，剃毛引起的产奶量增加与一些乳汁合成相关基因的表达减少存在矛盾的联系。此外，被剃毛的小鼠的乳腺的基因表达谱表明，相对于未剃毛的小鼠，其乳腺退化较早。一旦被赋予增强的散热能力，被剃毛的老鼠可能会比未剃毛的母亲更快地抚养幼崽独立。在线版本包含可在 10.1007/s00360-023-01474-9 获取的补充材料。
Peak lactation occurs when milk production is at its highest. The factors limiting peak lactation performance have been subject of intense debate. Milk production at peak lactation appears limited by the capacity of lactating females to dissipate body heat generated as a by-product of processing food and producing milk. As a result, manipulations that enhance capacity to dissipate body heat (such as fur removal) increase peak milk production. We investigated the potential correlates of shaving-induced increases in peak milk production in laboratory mice. By transcriptomic profiling of the mammary gland, we searched for the mechanisms underlying experimentally increased milk production and its consequences for mother–young conflict over weaning, manifested by advanced or delayed involution of mammary gland. We demonstrated that shaving-induced increases in milk production were paradoxically linked to reduced expression of some milk synthesis-related genes. Moreover, the mammary glands of shaved mice had a gene expression profile indicative of earlier involution relative to unshaved mice. Once provided with enhanced capacity to dissipate body heat, shaved mice were likely to rear their young to independence faster than unshaved mothers. The online version contains supplementary material available at 10.1007/s00360-023-01474-9.
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影响因子：
4.4
作者：
Ramanathan, Palaniappan;Martin, Ian C.;Gardiner-Garden, Margaret;Thomson, Peter C.;Taylor, Rosanne M.;Ormandy, Christopher J.;Moran, Christopher;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
9
作者：
通讯作者：
--
影响因子：
5.8
作者：
Farmaki, Elena;Kaza, Vimala;Kiaris, Hippokratis
通讯作者：
Kiaris, Hippokratis
影响因子：
10.5
作者：
Chapman, RS;Lourenco, PC;Watson, CJ
通讯作者：
Watson, CJ
RAB6 GTPase通过控制STAT5的激活来调节乳腺分泌功能。
DOI：
10.1242/dev.190744
发表时间：
2020-10-08
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Cayre S;Faraldo MM;Bardin S;Miserey-Lenkei S;Deugnier MA;Goud B
通讯作者：
Goud B