Physical mapping of the 5 Mb D9S196‐D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region
Physical mapping of the 5 Mb D9S196‐D9S180 interval harboring the basal cell nevus syndrome gene and localization of six genes in this region
复制标题
含有基底细胞痣综合征基因的 5 Mb D9S196-D9S180 区间的物理图谱以及该区域六个基因的定位
DOI：
--
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
E. Epstein
中科院分区：
文献类型：
--
作者：
Jingwu Xie;Anthony Quinn;Xiaoli Zhang;J. Bare;Alana L. Rothman;C. Collins;S. Cutone;M. Rutter;M. K. McCormick;E. Epstein
基底细胞痣综合征(Gorlin综合征)以多发性基底细胞癌和各种发育缺陷为特征。导致这种综合征的基因此前已经被定位在D9S196和D9S180之间2 cM的9q22.3处，最近在这个区域发现了一个候选基因的突变--果蝇补丁基因的人类同源基因。我们在这里报道了物理作图研究，整合了酵母人工染色体和细菌人工染色体的重叠群，以及在重组决定的侧翼标记之间跨越大约5Mb的长距离图谱。有六个基因被定位到这个区间。基因染色体。癌症18：305-309,1997。©1997 Wiley-Liss，Inc.
The basal cell nevus syndrome (Gorlin syndrome) is characterized by multiple basal cell carcinomas and diverse developmental defects. The gene responsible for this syndrome has been mapped previously to a 2 cM interval between D9S196 and D9S180 at 9q22.3, and very recently mutations of a candidate gene in this region—the human homolog of the Drosophila patched gene—have been identified. We report here on physical mapping studies integrating a contig of yeast artificial chromosomes and bacterial artificial chromosomes with a long‐range map spanning approximately 5 Mb between the recombination‐determined flanking markers. Six genes have been mapped to this interval. Genes Chromosom. Cancer 18:305–309, 1997. © 1997 Wiley‐Liss, Inc.
影响因子：
4.4
作者：
D. Munroe;M. Haas;E. Bric;Tania Whitton;H. Aburatani;K. Hunter;D. Ward;D. Housman
通讯作者：
D. Munroe;M. Haas;E. Bric;Tania Whitton;H. Aburatani;K. Hunter;D. Ward;D. Housman