Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).
Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review).
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DOI：
10.3892/ijo.22.1.15
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发表时间：
2003
影响因子：
5.2
通讯作者：
Sudhir Gupta
中科院分区：
文献类型：
--
作者：
Sudhir Gupta
近年来，对死亡受体和线粒体凋亡途径的分子机制的研究取得了重大进展。NF-κ B介导的存活（抗凋亡）信号的机制已被描述。已经确定了FLIP在RIP和TRAF-1和TRAF-2的募集中激活ERK和NF-κ B的新的抗凋亡机制。这些都是最近发现的死亡受体和线粒体途径的细胞凋亡，已在这篇文章中进行了审查。
In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to activate ERK and NF-kappaB has been defined. These are some of the recent discoveries in death receptor and mitochondrial pathways of apoptosis that have been reviewed in this article.