CANINE ORAL MELANOMA - COMPARISON OF SURGERY VERSUS SURGERY PLUS CORYNEBACTERIUM-PARVUM
CANINE ORAL MELANOMA - COMPARISON OF SURGERY VERSUS SURGERY PLUS CORYNEBACTERIUM-PARVUM
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DOI：
10.3109/07357908609017520
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发表时间：
1986-01-01
影响因子：
2.4
通讯作者：
MATUS, R
中科院分区：
文献类型：
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作者：
MACEWEN, EG;PATNAIK, AK;MATUS, R
89只患有恶性和黑色素瘤的狗被选择用于研究。所有狗均进行临床分期，并单独进行手术切除或手术加C治疗。小免疫疗法两个治疗组之间的生存时间无差异。然而，在患有晚期疾病（II、III期）的犬中，单独手术与手术加C之间存在统计学差异。小（p = 0.01）。患有第1阶段疾病（肿瘤直径<2cm）的狗具有统计学上改善的存活率（p = 0.02），无论给予何种治疗。这些结果表明C.当与手术结合时，parvum可能在犬黑素瘤模型中具有抗肿瘤活性。
Eighty-nine dogs with malignant and melanoma were selected for study. All dogs were clinically staged and treated with either surgical excision alone or surgery plus C. parvum immunotherapy. There was no difference in survival time between the two treatment groups. However, in dogs with advanced disease (Stages II, III) there was a statistical difference between surgery alone versus surgery plus C. parvum (p = 0.01). Dogs with Stage 1 disease (tumor < 2 cm diameter) had a statistically improved survival (p = 0.02) regardless of the therapy given. These results suggest that C. parvum, when combined with surgery, may have antitumor activity in the canine melanoma model.