Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome
Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome
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DOI：
10.1152/ajpregu.00729.2005
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发表时间：
2006-08-01
影响因子：
2.8
通讯作者：
Naliboff, Bruce D.
中科院分区：
文献类型：
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作者：
Chang, Lin;Mayer, Emeran A.;Naliboff, Bruce D.
在肠易激综合征（IBS）患者中，性别与内脏刺激敏感性之间的关系尚不完全清楚。我们的目的是评估性别对肠易激综合征内脏刺激的知觉反应的影响。58名IBS患者（平均年龄42 +/- 1岁，34名男性，24名女性）和26名健康对照（平均年龄38 +/- 3岁，9名男性，17名女性）接受了压力器辅助的直肠和乙状结肠扩张。在重复有害乙状结肠刺激（SIG， 60毫米汞柱脉冲）前后，采用随机、相位扩张模式测量直肠不适阈值。性对直肠不适阈值有显著影响。与IBS男性（38 +/- 2.3 mmHg）和最不敏感的健康女性（41.9 +/- 3.2 mmHg）相比，IBS女性最敏感（阈值较低[27 +/- 2.7 mmHg]，评分较高），直肠不适阈值显著降低。健康男性（34 +/- 4.3 mmHg）和IBS患者的直肠不适阈值无显著差异。在IBS组和对照组中，女性在有害乙状结肠刺激后的不适阈值显著降低（P < 0.01），而男性则没有。性别显著影响直肠乙状结肠扩张的知觉敏感性。女性对这种模式表现出更强的感性反应。
In irritable bowel syndrome (IBS) patients, the relationship between sex and sensitivity to visceral stimuli is incompletely understood. Our aim was to evaluate the effect of sex on perceptual responses to visceral stimulation in IBS. Fifty-eight IBS patients (mean age 42 +/- 1 yr; 34 men, 24 women) and 26 healthy controls (mean age 38 +/- 3 yr; 9 men, 17 women) underwent barostat-assisted distensions of the rectum and sigmoid colon. Rectal discomfort thresholds were measured using a randomized, phasic distension paradigm before and after repeated noxious sigmoid stimulation (SIG, 60-mmHg pulses). Sex had a significant effect on rectal discomfort thresholds. Women with IBS were the most sensitive ( lower thresholds [27 +/- 2.7 mmHg] and higher ratings), with significantly lower rectal discomfort thresholds compared with men with IBS (38 +/- 2.3 mmHg) and healthy women who were the least sensitive (41.9 +/- 3.2 mmHg; both P < 0.01). There were no significant differences in rectal discomfort thresholds between healthy men (34 +/- 4.3 mmHg) and men with IBS. Across both IBS and control groups, women demonstrated a significant lowering of discomfort thresholds after noxious sigmoid stimulation (P < 0.01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm.