Suzuki-Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs
Suzuki-Miyaura Cross-Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs
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DOI：
10.1021/jo3021665
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发表时间：
2012-11-16
影响因子：
3.6
通讯作者：
Molander, Gary A.
中科院分区：
文献类型：
--
作者：
Fleury-Bregeot, Nicolas;Presset, Marc;Molander, Gary A.
将烷氧基乙基部分引入到芳族亚结构上一直是合成有机化学家的长期挑战。主要原因是烷氧基乙基金属物种固有的不稳定性和缺乏获得它们的一般程序。已经开发了一种基于有机三氟硼酸盐的特殊性质的利用交叉偶联策略的新方法，并且该方法允许在广泛的芳基和杂芳基溴上容易且有效地安装该单元。
The introduction of an alkoxyethyl moiety onto aromatic substructures has remained a long-standing challenge for synthetic organic chemists. The main reasons are the inherent instability of alkoxyethylmetallic species and the lack of general procedures to access them. A new method utilizing a cross-coupling strategy based on the exceptional properties of organotrifluoroborates has been developed, and the method allows an easy and efficient installation of this unit on a broad range of aryl and heteroaryl bromides.