Effects of chronic caffeine pre-exposure on conditioned and unconditioned psychomotor activity induced by nicotine and amphetamine in rats.
Effects of chronic caffeine pre-exposure on conditioned and unconditioned psychomotor activity induced by nicotine and amphetamine in rats.
复制标题
慢性咖啡因预暴露对尼古丁和安非他明诱导的大鼠条件和非条件精神运动活动的影响。
DOI：
10.1097/00008877-200305000-00002
复制
发表时间：
2003
影响因子：
1.6
通讯作者：
Bevins,RA
中科院分区：
文献类型：
--
作者：
Palmatier,MI;Fung,EYK;Bevins,RA
三个实验研究了慢性预暴露于咖啡因对大鼠尼古丁或苯丙胺随后的条件和非条件运动激活效应的影响。大鼠每天腹腔注射无水咖啡因（0、10或30 mg/kg碱）30天。条件反射（环境-药物配对）在咖啡因预暴露的最后一天后开始。预先暴露于30毫克/公斤的咖啡因增强急性和慢性运动的安非他明（0.5毫克/公斤）的影响。高剂量（0.421 mg/kg碱）或低剂量（0.175 mg/kg）尼古丁均未观察到类似的活性增强。在无药物测试中，与安非他明和高剂量尼古丁配对的独特环境诱发了相对于对照组的活动增加。咖啡因预暴露不影响这种条件性多动症的表达。这些影响的咖啡因预暴露安非他明诱导的活动不能归因于咖啡因的非特异性影响。
Three experiments examined the effects of chronic pre-exposure to caffeine on the subsequent conditioned and unconditioned locomotor activating effects of nicotine or amphetamine in rats. Rats were given daily intraperitoneal injections of caffeine anhydrous (0, 10 or 30 mg/kg base) for 30 days. Conditioning (environment–drug pairings) began after the last day of caffeine pre-exposure. Pre-exposure to 30 mg/kg of caffeine enhanced the acute and chronic locomotor effects of amphetamine (0.5 mg/kg). A similar enhancement of activity was not seen with the high (0.421 mg/kg base) or low dose (0.175 mg/kg) of nicotine. In a drug-free test, the distinct environment paired with amphetamine and the high dose of nicotine evoked increases in activity relative to controls. Caffeine pre-exposure did not affect expression of this conditioned hyperactivity. These effects of caffeine pre-exposure on amphetamine-induced activity could not be attributed to non-specific effects of caffeine.