Extracellular and Intracellular Skeletons: How Do They Involve in Apoptosis
Extracellular and Intracellular Skeletons: How Do They Involve in Apoptosis
复制标题
细胞外和细胞内骨骼：它们如何参与细胞凋亡
DOI：
10.1089/dna.2021.0613
复制
发表时间：
2021
影响因子：
3.1
通讯作者：
Wan-Xi Yang
中科院分区：
文献类型：
--
作者：
Jia-Hao Ni;Wan-Xi Yang
细胞凋亡在清除异常或衰老细胞、维持组织的整体健康和协调个体发育方面起着关键作用。近年来，研究发现细胞骨架在细胞凋亡过程中起重要作用。此外，细胞外基质（ECM）纤维蛋白，可被认为是细胞外骨架，在细胞凋亡过程中的调节作用很少总结。本文就纤维蛋白在细胞内外如何调控细胞凋亡的最新研究进展进行综述。我们描述了ECM纤维蛋白如何通过整合素介导的各种信号级联反应参与死亡受体和线粒体途径的调节。然后，我们探讨了细胞内中间丝通过调节细胞膜表面的死亡受体来调节细胞凋亡的分子机制。同样，我们报告新的支持功能的微管在执行阶段的细胞凋亡，并讨论其形成机制。最后讨论了caspase降解ECM纤维蛋白和细胞内中间丝形成的多肽片段作为局部调节信号在细胞凋亡中发挥不同的调节作用。
Apoptosis plays a key role in removing abnormal or senescent cells, maintaining the overall health of the tissue, and coordinating individual development. Recently, it has been discovered that the intracellular cytoskeleton plays a role in the apoptotic process. In addition, the regulatory role of extracellular matrix (ECM) fibrous proteins, which can be considered as the extracellular skeleton, in the process of apoptosis is rarely summarized. In this review, we collect the latest knowledge about how fibrous proteins inside and outside cells regulate apoptosis. We describe how ECM fibrous proteins participate in the regulation of death receptor and mitochondrial pathways through various signaling cascades mediated by integrins. We then explore the molecular mechanisms by which intracellular intermediate filaments regulate cell apoptosis by regulating death receptors on the cell membrane surface. Similarly, we report on novel supporting functions of microtubules in the execution phase of apoptosis and discuss their formation mechanisms. Finally, we discuss that the polypeptide fragments formed by caspase degradation of ECM fibrous proteins and intracellular intermediate filament act as local regulatory signals to play different regulatory roles in apoptosis.