Relationship between serum 3,5,3'-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness
Relationship between serum 3,5,3'-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness
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DOI：
10.1007/bf03349894
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发表时间：
1996-07-01
影响因子：
5.4
通讯作者：
Wiersinga, WM
中科院分区：
文献类型：
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作者：
Boelen, A;PlatvoetterSchiphorst, MC;Wiersinga, WM
为了进一步阐明细胞因子在低T-3综合征发病机制中的作用，我们研究了99例因各种非甲状腺疾病而连续住院的患者血清T-3与血清干扰素γ (IFN γ)、白细胞介素8 （IL-8）和白细胞介素10 （IL-10）之间的关系；没有人使用影响甲状腺激素代谢的药物。将患者分为A组（正常血清T-3和T-4）、B组（亚正常血清T-3和T-4）和C组（亚正常血清T-3和T-4）。血清IFN γ、IL-8、IL-10在A、B、C组间无显著差异（除B组IFN γ有少量升高）。血清T-3与血清IL-8有轻微相关性(r=0.25, p
In order to further delineate the role of cytokines in the pathogenesis of the low T-3 syndrome, we studied the association between serum T-3 and serum interferon gamma (IFN gamma), interleukin-8 (IL-8) and interleukin-10 (IL-10) in 99 consecutive patients hospitalised because of a wide variety of nonthyroidal diseases; none used drugs affecting thyroid hormone metabolism. Patients were divided in group A (normal serum T-3 and T-4), group B (sub-normal serum T-3 and normal T-4) and group C (sub- normal T-3 and T-4). Serum IFN gamma, IL-8 and IL-10 were not different between group A, B and C (with the exception of a small increase of IFN gamma in group B). Serum T-3 was slightly related to serum IL-8 (r=0.25, p