Neutrophil CD64 as a diagnostic marker of sepsis: impact on neonatal care.
Neutrophil CD64 as a diagnostic marker of sepsis: impact on neonatal care.
复制标题
中性粒细胞 CD64 作为脓毒症的诊断标志物：对新生儿护理的影响。
DOI：
10.1055/s-0034-1384644
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发表时间：
2015
影响因子：
2
通讯作者：
Kingma,PaulS
中科院分区：
文献类型：
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作者：
Lynema,Stephanie;Marmer,Daniel;Hall,EricS;Meinzen-Derr,Jareen;Kingma,PaulS
本研究的目的是确定中性粒细胞CD64在识别感染婴儿中的有效性和可靠性，并评估该标志物对临床护理的影响。结果中性粒细胞CD64检测的敏感性为87%，在确定31次培养阳性败血症和83%确定12名婴儿呼吸机相关性肺炎。CD64正常婴儿与全血细胞计数（CBC）正常婴儿的平均抗生素使用天数无差异（p= 0.89），但CD64被确定为“未感染”的婴儿是CBC的2倍。结论CD64对识别感染婴儿具有较高的敏感性，同时也减少了暴露于不必要抗生素使用的婴儿数量。
ObjectiveThe aim of this study is to determine the validity and reliability of neutrophil CD64 in identifying infected infants and to evaluate the impact of this marker on clinical care.Study DesignNeutrophil CD64 index was incorporated in 371 infection evaluations in 234 infants (ages 1–293 days) from 2005 to 2009 and the impact of this change on clinical care was evaluated.ResultsThe sensitivity of the neutrophil CD64 assay was 87% in identifying 31 episodes of culture positive sepsis and 83% in identifying 12 infants with ventilator-associated pneumonia. There was no difference in the mean number of antibiotic days in infants with a normal CD64 versus those with a normal complete blood count (CBC) (p= 0.89), but twofold more infants were identified as “not infected” by CD64 than by CBC.ConclusionCD64 had a high sensitivity for identifying infected infants while also decreasing the number of infants that were exposed to unnecessary antibiotic use.