The CPTAC Data Portal: A Resource for Cancer Proteomics Research
The CPTAC Data Portal: A Resource for Cancer Proteomics Research
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DOI：
10.1021/pr501254j
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发表时间：
2015-06-01
影响因子：
4.4
通讯作者：
Ketchum, Karen A.
中科院分区：
文献类型：
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作者：
Edwards, Nathan J.;Oberti, Mauricio;Ketchum, Karen A.
临床蛋白质组学肿瘤分析联盟 (CPTAC) 在美国国家癌症研究所癌症临床蛋白质组学研究办公室的支持下，是一项全面、协调的工作，旨在通过将蛋白质组学技术和工作流程应用于具有特征基因组和转录谱特征的临床肿瘤样本，加速对癌症分子基础的了解。该联盟使用质谱分析癌症生物样本，识别和量化组成蛋白并表征每个肿瘤样本的蛋白质组。质谱分析能够高度特异性地鉴定蛋白质及其亚型，对对比生物样本中的蛋白质丰度进行准确的相对定量，以及翻译后蛋白质修饰（例如蛋白质序列上的磷酸化）的定位。来自同一临床肿瘤样本的蛋白质组学、转录组学和基因组学数据的结合为肿瘤蛋白质组学提供了前所未有的机会。 CPTAC 数据门户是一个集中式数据存储库，用于传播联盟中蛋白质组表征中心 (PCC) 收集的蛋白质组数据。该门户目前拥有 6.3 TB 数据，包括来自癌症基因组图谱 (TCGA) 的乳腺癌、结直肠癌和卵巢肿瘤组织的蛋白质组学研究。该联盟收集的数据通过数据门户免费向公众开放。
The Clinical Proteomic Tumor Analysis Consortium (CPTAC), under the auspices of the National Cancer Institute's Office of Cancer Clinical Proteomics Research, is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of proteomic technologies and workflows to clinical tumor samples with characterized genomic and transcript profiles. The consortium analyzes cancer biospecimens using mass spectrometry, identifying and quantifying the constituent proteins and characterizing each tumor sample's proteome. Mass spectrometry enables highly specific identification of proteins and their isoforms, accurate relative quantitation of protein abundance in contrasting biospecimens, and localization of post-translational protein modifications, such as phosphorylation, on a protein's sequence. The combination of proteomics, transcriptomics, and genomics data from the same clinical tumor samples provides an unprecedented opportunity for tumor proteogenomics. The CPTAC Data Portal is the centralized data repository for the dissemination of proteomic data collected by Proteome Characterization Centers (PCCs) in the consortium. The portal currently hosts 6.3 TB of data and includes proteomic investigations of breast, colorectal, and ovarian tumor tissues from The Cancer Genome Atlas (TCGA). The data collected by the consortium is made freely available to the public through the data portal.