Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: Determinants of survival
Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: Determinants of survival
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DOI：
10.1086/514311
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发表时间：
1999-02-01
影响因子：
6.4
通讯作者：
Ksiazek, TG
中科院分区：
文献类型：
--
作者：
Sadek, RF;Khan, AS;Ksiazek, TG
1995年5月，一个国际小组查明并控制了刚果民主共和国基奎特爆发的埃博拉出血热。本研究报告了此次爆发的描述性特征以及爆发数据的统计分析。采用比例风险分析考察年龄、发病阶段和性别对死亡风险的影响，采用条件概率分析考察康复期患者全血输注对生存的影响。死亡250例（80.7%）。在比例风险模型中，生存的主要预测因子是年龄。在调整了年龄、性别和出现症状的天数后，没有明显的统计证据表明从恢复期患者输血对生存有好处（P = 0.1713）。
In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7%) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).