Velocity alignment leads to high persistence in confined cells.
Velocity alignment leads to high persistence in confined cells.
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DOI：
10.1103/physreve.89.062705
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Rappel WJ
中科院分区：
文献类型：
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作者：
Camley BA;Rappel WJ
我们研究了一个简单的模型，爬行细胞作为一个活跃的布朗粒子，它的极性方向，其速度，一种机制，以前已经提出来描述集体细胞迁移。我们表明，准一维约束下，速度对齐细胞从随机行走运动过渡到一个高度持久的爬行运动。这个问题可以被映射到一个经典的扩散逃逸的障碍和解析解决，以确定细胞的取向分布和复极率。细胞的复极化时间随着速度排列强度的增加而呈指数增加。我们将这种行为的实验表明，限制在微通道和粘附微图案的细胞发展强大的定向迁移，并描述准一维局限的细胞的集体运动。
We study a simple model of a crawling cell as an active Brownian particle that aligns its polarity direction to its velocity, a mechanism that has been previously proposed to describe collective cell migration. We show that under quasi-one-dimensional confinement, velocity-aligning cells transition from a random-walk motility to a highly persistent crawling motion. This problem can be mapped to a classical diffusive escape over a barrier and analytically solved to determine the cell’s orientation distribution and repolarization rate. The cell’s repolarization time increases exponentially as the strength of the velocity alignment is increased. We relate this behavior to experiments showing that cells confined in microchannels and on adhesive micropatterns develop strong directional migration, and describe collective motion of quasi-one-dimensionally confined cells.