DEVELOPMENT OF BARRELS AND BARREL FIELD IN SOMATOSENSORY CORTEX OF MOUSE
DEVELOPMENT OF BARRELS AND BARREL FIELD IN SOMATOSENSORY CORTEX OF MOUSE
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DOI：
10.1002/cne.901710408
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发表时间：
1977-01-01
影响因子：
2.5
通讯作者：
VANDERLOOS, H
中科院分区：
文献类型：
--
作者：
RICE, FL;VANDERLOOS, H
在出生后第4天，小鼠体感觉皮层PMBSF的桶状区（后内侧桶状亚区）在nsil染色切向切片上同时变得明显。此时，它们是成人的微缩模型，位于三椎体皮质板最深的板下。早期的管状体表现为细胞密度降低的斑块：管状体的前瞻性中空。产后第六天出现明显的隔脓。从成年期开始，PMBSF对总皮质表面积的相对贡献增加了，这种增加与人们的预期相反：与桶相关的外周非常早成熟，皮层的中央和外侧区域也是如此。平行于柱面的筒体生长沿长轴大于沿小轴。通过使用桶状体识别未成熟皮层的未来第四层，确定了V层和VI层在出生后第6天达到成年高度，而未来I-IV层只有其成年高度的一半。桶状形成的开始与相关体感觉外周（振动乳头）的损伤不再引起桶状形态的深刻改变的时刻一致。
Barrels of the PMBSF [posteromedial barrel subfield] of the mouse somatosensory cortex became apparent in Nissl-stained tangential sections simultaneously, on the 4th postnatal day. At this time they were miniatures of those in the adult and were situated in the deepest sublamina of the trilaminar cortical plate. An early barrel appeared as a patch of decreased cell density: the prospective hollow of the barrel. Septa became noticeable during the 6th postnatal day. From that period of adulthood, the relative contribution of the PMBSF to the total cortical surface area increased, an increase that goes against one''s expectation: the barrel related periphery matured very early and so did the central, lateral region of the cortex. Barrel growth parallel to the pial surface was greater along the major axes than along the minor axes. By using the barrels to identify prospective layer IV in immature cortex, it was determined that layers V and VI attained their adult height during the 6th postnatal day, an age when prospective layers I-IV were only half their adult height. The onset of barrel formation coincided with the moment after which injury to the pertinent somatosensory periphery (the vibrissal papillae) no longer caused profound alterations in barrel morphology.