Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.
Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.
复制标题
血清色氨酸降低与结直肠癌的免疫激活和生活质量受损相关。
DOI：
10.1038/sj.bjc.6600336
复制
发表时间：
2002-06-05
影响因子：
8.8
通讯作者：
Allen-Mersh, T G
中科院分区：
文献类型：
--
作者：
Huang, A;Fuchs, D;Widner, B;Glover, C;Henderson, D C;Allen-Mersh, T G
干扰素-γ上调癌症相关吲哚胺（2，3）-双加氧酶可能通过消耗血清色氨酸影响生活质量。我们将血清色氨酸水平与结直肠癌肝转移患者的免疫激活和生活质量相关联。从完成生活质量和心理问卷的原发性结直肠癌患者和异时性结直肠肝转移患者中采集静脉血。检测血清色氨酸、犬尿氨酸、新喋呤、白细胞介素2可溶性受体α（IL-2 sRα）、可溶性肿瘤坏死因子受体I（sTNF RI）、白细胞介素6和C反应蛋白。通过计算机断层扫描估计肝转移体积，并记录血液采样的存活率。研究了66例结直肠癌患者（39例男性;中位年龄66岁），其中25例仅发生结直肠肝转移（17例男性;中位年龄62岁;中位肝转移体积208 ml;中位生存期234天）。血清色氨酸降低与鹿特丹症状自评量表躯体症状（r=−0.51，P=0.01）和疾病影响特征（r=−0.42，P=0.04）评分显著相关，并与血清新喋呤（r=−0.36，P=0.003）、IL-2 sRα（r=−0.51，P=0.01）和sTNF RI（r=−0.45，P=0.02）水平升高相关。逐步回归分析表明，血清色氨酸是鹿特丹症状清单身体症状（回归系数-20.78，P=0.01）和疾病影响概况（回归系数-109.09，P=0.04）评分的独立预测因子。结果支持干扰素-γ介导的血清色氨酸降低在癌症诱导的生活质量恶化中的作用。英国癌症杂志（2002）86，1691-1696。www.bjcancer.com © 2002英国癌症研究中心
Cancer-related indoleamine (2,3)-dioxygenase up-regulation by interferon-γ might influence quality of life by depleting serum tryptophan. We correlated serum tryptophan levels with immune activation and quality of life in patients with colorectal liver metastases. Venous blood was sampled from patients with primary colorectal cancer and from patients with metachronous colorectal liver metastases who completed quality of life and psychological questionnaires. Serum tryptophan, kynurenine, neopterin, interleukin 2 soluble receptor α (IL-2 sRα), soluble tumour necrosis factor receptor I (sTNF RI), interleukin 6, and C-reactive protein were measured. Liver metastasis volume was estimated by computerised tomography, and survival from blood sampling was noted. Sixty-six patients with colorectal cancer were studied (39 males; median age 66 years) of whom 25 had colorectal liver metastases only (17 males; median age 62 years; median liver metastasis volume 208 ml; median survival 234 days). Reduced serum tryptophan was significantly associated with Rotterdam Symptom Checklist physical symptom (r=−0.51, P=0.01) and Sickness Impact Profile (r=−0.42, P=0.04) scores, and correlated with increased serum neopterin (r=−0.36, P=0.003), IL-2 sRα (r=−0.51, P=0.01) and sTNF RI (r=−0.45, P=0.02) levels. Stepwise regression analyses suggested that serum tryptophan was an independent predictor of Rotterdam Symptom Checklist physical symptom (regression coefficient −20.78, P=0.01) and Sickness Impact Profile (regression coefficient −109.09, P=0.04) scores. The results supported a role for interferon-γ-mediated serum tryptophan decrease in cancer-induced quality of life deterioration. British Journal of Cancer (2002) 86, 1691–1696. doi:10.1038/sj.bjc.6600336 www.bjcancer.com © 2002 Cancer Research UK