Anxiety in the elevated zero-maze is augmented in mice after repeated daily exposure
Anxiety in the elevated zero-maze is augmented in mice after repeated daily exposure
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DOI：
10.1023/a:1015249706579
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发表时间：
2002-03-01
影响因子：
2.6
通讯作者：
Flaherty, L
中科院分区：
文献类型：
--
作者：
Cook, MN;Crounse, M;Flaherty, L
我们最近在高架零迷宫中连续 3 天测试了三种近交小鼠品系（C57BL/6J、DBA/2J、C3H/HeJ）和两种 F1 杂交小鼠（B6C3F1/J、C3D2F1/J）。根据进入开放象限的潜伏期和在开放区域花费的时间百分比来衡量，三项试验的焦虑程度有所增加。此外，我们观察到一些菌株在初次暴露时使用视觉提示来避免零迷宫的张开臂，而其他菌株可能使用其他感官提示。这些结果表明，菌株不同地使用或保留从最初暴露中收集的信息，以避免随后暴露于迷宫时出现开放象限。此外，这种重复的试验可能更准确地反映视力受损品系的焦虑程度。
We recently tested three inbred mouse strains (C57BL/6J, DBA/2J, C3H/HeJ) and two F1 hybrids (B6C3F1/J, C3D2F1/J) in an elevated zero-maze for 3 consecutive days. As measured by the latency to enter an open quadrant and percentage of time spent in the open, anxiety increased over the three trials. Furthermore, we observed that some strains used visual cues to avoid the open arms of the zero-maze on the initial exposure, while other strains may have used other sensory cues. These results suggest that strains differentially use or retain information, gathered from the initial exposure, to avoid the open quadrants on subsequent exposure to the maze. Moreover, this repeated trial test may more accurately reflect anxiety in strains that are visually impaired.