The association of pericardial fat with calcified coronary plaque
The association of pericardial fat with calcified coronary plaque
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DOI：
10.1038/oby.2008.278
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发表时间：
2008-08-01
期刊：
影响因子：
6.9
通讯作者：
Carr, J. Jeffrey
中科院分区：
文献类型：
--
作者：
Ding, Jingzhong;Kritchevsky, Stephen B.;Carr, J. Jeffrey
背景：心包脂肪比皮下脂肪具有更高的炎性细胞因子分泌量。冠状动脉周围的心包脂肪释放的细胞因子可能局部作用于邻近的细胞。目的：我们研究了心包脂肪与钙化冠状动脉斑块的关系。方法和程序：2000/2002年间，参加以社区为基础的多种族动脉粥样硬化研究(MESA)的参与者接受了计算机断层扫描(CT)以评估钙化冠状动脉斑块。我们使用这些扫描测量了来自北卡罗来纳州福赛斯县的159名没有冠心病症状的白人和黑人的心包脂肪体积。结果：91名参与者(57%)观察到了钙化的冠状动脉斑块。在调整高度后，1S.D.心包脂肪的增加与钙化冠状动脉斑块的风险增加相关(优势比(95%可信区间)：1.92(1.27，2.90))。随着其他心血管因素的进一步调整，心包脂肪仍与冠状动脉钙化斑块显著相关。这种关系不因性别和种族而异。另一方面，体重指数和调整身高的腰围与钙化冠状动脉斑块无关。
Background: Pericardial fat has a higher secretion of inflammatory cytokines than subcutaneous fat. Cytokines released from pericardial fat around coronary arteries may act locally on the adjacent cells. Objective: We examined the relationship between pericardial fat and calcified coronary plaque.Methods and Procedures: Participants in the community-based Multi-Ethnic Study of Atherosclerosis (MESA) underwent a computed tomography (CT) scan for the assessment of calcified coronary plaque in 2000/2002. We measured the volume of pericardial fat using these scans in 159 whites and blacks without symptomatic coronary heart disease from Forsyth County, NC, aged 55-74 years.Results: Calcified coronary plaque was observed in 91 participants (57%). After adjusting for height, a 1 s.d. increment in pericardial fat was associated with an increased odds of calcified coronary plaque (odds ratio (95% confidence interval): 1.92 (1.27, 2.90)). With further adjustment of other cardiovascular factors, pericardial fat was still significantly associated with calcified coronary plaque. This relationship did not differ by gender and ethnicity. On the other hand, BMI and height-adjusted waist circumference were not associated with calcified coronary plaque.Discussion: Pericardial fat is independently associated with calcified coronary plaque.