Actinobacillus pleuropneumoniae serotype 7 siderophore receptor FhuA is not required for virulence
Actinobacillus pleuropneumoniae serotype 7 siderophore receptor FhuA is not required for virulence
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DOI：
10.1016/s0378-1097(03)00064-8
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发表时间：
2003-03-14
影响因子：
2.1
通讯作者：
Gerlach, GF
中科院分区：
文献类型：
--
作者：
Baltes, N;Tonpitak, W;Gerlach, GF
在胸膜肺炎放线杆菌血清型7中鉴定了一种铁色素受体FhuA。构建了铁色素摄取受体基因（fhuA）缺失的同基因突变体，并在气溶胶感染模型中进行了研究。该突变体引起的病害与A.胸膜肺炎血清型7野生型：缺乏摄取转铁蛋白结合铁所需的exbB基因表达的同基因突变体保留了利用铁色素的能力，从而表明铁色素转运中涉及的能量偶联机制仍有待鉴定。(C)2003年，欧洲微生物学会联合会。由Elsevier Science B.V.出版，版权所有。
A ferrichrome receptor, FhuA, was identified in Actinobacillus pleuropneumoniae serotype 7. An isogenic mutant with a deletion in the ferrichrome uptake receptor gene (fhuA) was constructed and examined in an aerosol infection model. The disease caused by the mutant was indistinguishable from disease induced by A. pleuropneumoniae serotype 7 wild-type: an isogenic mutant lacking expression of the exbB gene that is required for the uptake of transferrin-bound iron retained the ability to utilize ferrichrome, thereby indicating that an energy-coupling mechanism involved in ferrichrome transport remains to be identified. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.