D2 dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat striatum.
D2 dopamine receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat striatum.
复制标题
D2 多巴胺受体介导的毛喉素刺激的大鼠纹状体腺苷酸环化酶活性的抑制。
DOI：
10.1016/0304-3940(85)90196-x
复制
发表时间：
1985
影响因子：
2.5
通讯作者：
Creese,I
中科院分区：
文献类型：
--
作者：
Battaglia,G;Norman,AB;Hess,EJ;Creese,I
Forskolin markedly stimulates striatal adenylate cyclase activity in a concentration-dependent manner, and at 10−4M produces an approximate 40-fold increase in enzyme activity above basal levels. Dopamine (in the presence of 100 nM SCH 23390), bromocryptine and quinpirole (LY 171555) significantly inhibit both basal and forskolin-stimulated adenylate cyclase activity. There is a significant increase in the absolute but not in the percent inhibition of enzyme activity by dopaminergic agonists as a function of forskolin concentration. This inhibition is agonist-concentration dependent and antagonized by the D2antagonist, spiperone. These results suggest that forskolin may be used as a tool for amplifying the abolute D2-receptor-mediated inhibition of adenylate cyclase in rat striatal homogenates.
