Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity
Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity
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DOI：
10.1016/j.tripleo.2008.08.018
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发表时间：
2009-03-01
期刊：
影响因子：
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通讯作者：
Komori, Takahide
中科院分区：
文献类型：
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作者：
Kobayashi, Masaki;Shibuya, Yasuyuki;Komori, Takahide
在本研究中，研究了Ror2在口腔正常粘膜、上皮不典型增生和鳞状细胞癌（SCC）中的表达，并检查了Ror2与p53、Ki67或PCNA的表达模式可能存在的差异。 Western blotting分析显示，口腔癌中Ror2的表达显着高于正常口腔粘膜。免疫组织化学显示，Ror2 位于质膜和粗面内质网 (rER) 上。 Ror2阳性表达的组织区域与p53、ki67或PCNA阳性表达的区域有不同的倾向，并且Ror2表达的细胞数有随着上皮组织的恶性程度上升而增加的倾向。这些结果表明，Ror2与细胞增殖无关，而是与细胞极性和细胞运动有关，并且与口腔上皮组织的恶性程度密切相关。 （口腔外科、口腔医学、口腔病理、口腔放射学 Endod 2009；107：398-406）
In this study, the expressions of Ror2 in the normal mucosa, the epithelium dysplasia, and squamous cell carcinoma (SCC) of the oral cavity were investigated, and possible differences in the expression patterns of Ror2 and of p53, Ki67, or PCNA were examined. In Western blotting analyses, Ror2 expression in oral cancer was significantly higher than that in the normal oral mucosa. Immunohistochemically, Ror2 was localized on the plasmalemma and in the rough endoplasmic reticulum (rER). The tissue area with an Ror2-positive expression tended to differ from the area with a positive expression of p53, ki67, or PCNA, and the number of cells with an Ror2 expression tended to increase as the degree of malignancy rose in the epithelial tissues. These results suggest that Ror2 was not related to cell proliferation, but rather associated with cell polarity and cell motility, and that it was also closely associated with the degree of malignancy in oral epithelial tissue. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:398-406)