Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development
Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development
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DOI：
10.1002/glia.23818
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发表时间：
2020-03
期刊：
影响因子：
6.2
通讯作者：
Takumi Nakagawa;Yoshikuni Wada;Sayako Katada;Y. Kishi
中科院分区：
文献类型：
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作者：
Takumi Nakagawa;Yoshikuni Wada;Sayako Katada;Y. Kishi
神经系统由数百种神经元亚型和胶质细胞组成，这些细胞表现出特定的基因表达，并由共同的祖先神经干细胞（NSCs）产生。随着分析表观遗传学和染色质结构的实验技术和分子工具的迅速发展，发育中的NSCs中DNA甲基化、组蛋白修饰和染色质可及性的综合事件和全基因组状态逐渐被揭示。在这里，我们回顾了最近在阐明表观遗传和染色质调控在NSCs中的作用方面的进展，特别是关注胶质细胞身份的获得以及表观遗传调控如何在小鼠皮质发育过程中实现NSCs的时间调控。
The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome‐wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.