Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain
Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain
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DOI：
10.1016/s0169-328x(00)00190-x
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发表时间：
2000-10-20
期刊：
影响因子：
--
通讯作者：
Zoeller, RT
中科院分区：
文献类型：
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作者：
Dowling, ALS;Zoeller, RT
近年来的临床研究表明，甲状腺激素在胎儿脑发育中起重要作用。然而，甲状腺激素影响胎儿脑发育的机制研究甚少。我们最近确定了几个基因表达的胎儿皮质的丰度是受母体来源的甲状腺激素。然而，目前还不清楚这些基因是否直接受甲状腺激素的调节。因为这些是已知的第一个在胎儿发育过程中受甲状腺激素调节的基因，我们试图将我们的研究扩展到已知直接受甲状腺激素调节的基因。我们现在报告，众所周知的甲状腺激素反应基因RC 3/神经颗粒蛋白在胎儿大脑中表达，并受到母体来源的甲状腺激素的调节。这些发现支持了母体甲状腺激素对胎儿大脑中对正常神经发育重要的基因表达发挥直接作用的概念。(C)2000 Elsevier Science B. V.保留所有权利。
Recent clinical studies indicate that thyroid hormone plays essential roles in fetal brain development. However, the mechanism by which thyroid hormone affects fetal brain development is poorly studied. We recently identified several genes expressed in the fetal cortex whose abundance is affected by thyroid hormone of maternal origin. However, it is unclear whether these genes are directly regulated by thyroid hormone. Because these are the first genes known to be regulated by thyroid hormone during fetal development, we sought to expand our investigation to genes known to be regulated directly by thyroid hormone. We now report that the well-known thyroid hormone-responsive gene RC3/neurogranin is expressed in the fetal brain and is regulated by thyroid hormone of maternal origin. These findings support the concept that maternal thyroid hormone exerts a direct action on the expression of genes in the fetal brain that are important for normal neurological development. (C) 2000 Elsevier Science B.V. All rights reserved.