Helium-assisted enhanced discharge in a hollow needle for high-field asymmetric ion mobility spectrometry (FAIMS)
Helium-assisted enhanced discharge in a hollow needle for high-field asymmetric ion mobility spectrometry (FAIMS)
复制标题
用于高场不对称离子迁移谱 (FAIMS) 的空心针内氦辅助增强放电
DOI：
10.1007/s00216-021-03250-6
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发表时间：
2021
影响因子：
4.3
通讯作者：
Xiao Wenxiang
中科院分区：
文献类型：
--
作者：
Li Hua;Du Xiaoxia;Zeng Hongda;Huang Jienan;Li Minglei;Chen Zhencheng;Xiao Wenxiang
为了提高平面高场非对称离子迁移谱（FAIMS）的分辨能力，在以往的工作中采用了氮氦混合载气。本文研制了一种新型的空心针-环离子源，氦和氮分别从空心针和空心环进入。结果发现，丙酮，乙醇和乙酸乙酯的信号强度增加了8.5，2.0和3.3倍，分别为20%，20%和10%的氦比率。同时，补偿电压的绝对值和离子峰的数目增加。实验结果表明，在平面FAIMS中加入适当的氦氮比，可以同时提高灵敏度和分辨率，这在国内外尚属首次报道。
A carrier gas mixture of nitrogen and helium has been employed to improve the resolving power at the expense of sensitivity for planar high-field asymmetric ion mobility spectrometry (FAIMS) in previous work. In this paper, a new hollow needle-to-ring ion source was developed, where the helium and nitrogen enter from the hollow needle and ring, respectively. It was found that the signal strengths of acetone, ethanol, and ethyl acetate increased by 8.5, 2.0, and 3.3 times for helium ratios of 20%, 20%, and 10%, respectively. At the same time, the absolute value of compensation voltage and the number of ion peaks increases. It shows that adding an appropriate helium ratio to nitrogen simultaneously improved the sensitivity and resolving power of planar FAIMS, which is reported for the first time.