Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae.
Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae.
复制标题
抗日本血吸虫尾蚴三组分超分子水凝胶的形成和控制药物释放
DOI：
10.3390/nano6030046
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发表时间：
2016-03-09
期刊：
影响因子：
--
通讯作者：
Fan X
中科院分区：
文献类型：
--
作者：
Li Y;Zhu L;Fan Y;Li Y;Cheng L;Liu W;Li X;Fan X
构建了以核黄素、三聚氰胺和氨基酸衍生物为基材的新型三组分超分子水凝胶，用于农药、氯硝柳胺衍生物的控释。水凝胶的形成可能是通过氢键和π -π相互作用进行自组装，并通过扫描电子显微镜（SEM）和傅里叶变换红外光谱（FT-IR）进行了研究。流变学实验表明，水凝胶材料和载药水凝胶均表现出良好的机械强度和较高的稳定性。进一步的实验结果表明，载药水凝胶在水环境中具有载药量大、释放时间长、抗尾蚴效率较高的特点。
A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment.