Identification of FLRT1, FLRT2, and FLRT3:: A novel family of transmembrane leucine-rich repeat proteins
Identification of FLRT1, FLRT2, and FLRT3:: A novel family of transmembrane leucine-rich repeat proteins
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DOI：
10.1006/geno.1999.6033
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发表时间：
1999-12-15
期刊：
影响因子：
4.4
通讯作者：
Kunkel, LM
中科院分区：
文献类型：
--
作者：
Lacy, SE;Bönnemann, CG;Kunkel, LM
Flt1、Flrts和Flrts组成了一个新的基因家族，在肌肉中表达的细胞外基质蛋白的筛选中被分离出来。这三个基因编码I型跨膜蛋白，每个基因都包含10个富含亮氨酸的重复序列，两侧分别是N端和C端的半胱氨酸富集区，一个纤维连接蛋白/胶原蛋白样结构域，以及一个细胞内尾巴。在肾脏和脑中表达，在胰腺、骨骼肌、脑和心脏中表达，在肾脏、脑、胰腺、骨骼肌、肺、肝脏、胎盘和心脏中表达。Flt1定位于11q12-q13，FlrS定位于14q24-q32，Flrt3定位于20p11，在SF9和COSY细胞中表达时，分别以90 kDa和85 kDa的形式迁移，并且两者都是糖基化的。根据这三种蛋白质的总体结构，可以预测其在细胞黏附和/或受体信号传递中的作用。(C)1999年学术出版社。
FLRT1, FLRTS, and FLRTS comprise a novel gene family isolated in a screen for extracellular matrix proteins expressed in muscle. The three genes encode putative type I transmembrane proteins, each containing 10 leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich regions, a fibronectin/ collagen-like domain, and an intracellular tail. FLRT1 is expressed in kidney and brain, FLRTS is expressed in pancreas, skeletal muscle, brain, and heart, and FLRTS is expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart. FLRT1 localized to 11q12-q13, FLRTS to 14q24-q32, and FLRT3 to 20p11, When expressed in SF9 and COSY cells, FLRT1 and FLRTS migrate as 90- and 85-kDa proteins, respectively, and both are glycosylated. Given the overall structure of the three proteins, a function in cell adhesion and/or receptor signaling is predicted. (C) 1999 Academic Press.