A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China
A cluster of person-to-person transmission cases caused by SFTS virus in Penglai, China
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DOI：
10.1016/j.cmi.2014.10.006
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发表时间：
2015-03-01
影响因子：
14.2
通讯作者：
Xu, A. Q.
中科院分区：
文献类型：
--
作者：
Jiang, X. L.;Zhang, S.;Xu, A. Q.
一种新出现的传染病，严重发热伴血小板减少综合征（SFTS），被确定为与一种新的SFTS病毒（SFTSV）。该病在人与人之间的传播已有描述，但临床影响因素和传播机制仍需进一步研究。对山东省蓬莱县发生的一起SFTS人传人暴发疫情进行了调查。结果发现，8例继发性SFTS患者发病时间均在接触患者尸体后7 ~ 13 d，临床潜伏期多集中在9-10 d（n = 6）。两名死亡患者，包括索引患者和一名继发感染患者，表现出异常高水平的病毒载量（6 × 10（8-9）拷贝/mL），低水平的血小板计数（
An emerging infectious disease, severe fever with thrombocytopenia syndrome (SFTS), was identified to be associated with a novel SFTS virus (SFTSV). Transmission of the disease among humans has been described, but clinical impact factors and transmission mechanisms still need further study. An outbreak of person-to-person transmission of SFTS in a cluster of nine patients that occurred in an SFTS endemic area, Penglai County, Shandong province, China, was investigated. We found that the onset date of all eight secondary SFTS patients ranged from 7 to 13 days after exposure to the corpse of the index patient, and clinical incubation time was mostly focused on 9-10 days (n = 6). The two dead patients, including the index patient and one secondary infected patient, presented unusually high levels of viral load (6 x 10(8-9) copies/mL), low levels of platelets count (