Evaluation of apolipoprotein M as a biomarker of coronary artery disease
Evaluation of apolipoprotein M as a biomarker of coronary artery disease
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DOI：
10.1016/j.clinbiochem.2008.11.010
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发表时间：
2009-03-01
影响因子：
2.8
通讯作者：
Ye, Yizhou
中科院分区：
文献类型：
--
作者：
Su, Weiqiang;Jiao, Guoqing;Ye, Yizhou
目的：探讨载脂蛋白M（ApoM）在冠状动脉疾病（CAD）发生发展中的可能作用。设计与方法：病例对照研究，包括118例CAD患者和255名无关受试者作为对照组。采用血凝块印迹法测定血浆ApoM浓度，用Gensini评分或病变冠状动脉数目表示CAD的严重程度，并测量血脂水平。 结果与讨论：本研究显示，CAD患者血浆ApoM平均水平为1.3757+/-0.1493 ODu mm(-2)，而CAD患者血浆ApoM平均水平为1.3502+/-0.1288 ODu mm(-2)。对照组血浆ApoM水平存在显着性差异(t=0.032,P<0.05)。结论:ApoM不能作为CAD的独立危险因素,而是CAD的生物标志物。 (C) 2008 年加拿大临床化学家协会。由爱思唯尔公司出版。保留所有权利。
Objective: To investigate the possible role of apolipoprotein M (ApoM) in the development of coronary artery disease (CAD).Design and methods: Case-controlled study, which consisted of 118 CAD patients and 255 unrelated subjects used as control group. Plasma concentration of ApoM was determined by clot blot, severity of CAD was expressed with Gensini score or the numbers of lesioned coronary arteries, and serum lipid levels were also measured.Results and discussion: Our study shows the mean level of plasma ApoM is 1.3757 +/- 0.1493 ODu mm(-2) in CAD patients, while it is 1.3502 +/- 0.1288 ODu mm(-2) in control group, and there are significant differences in plasma level of ApoM between two groups (t=0.032, P0.05, respectively).Conclusion: The findings suggest that ApoM could not be an independent risk factor but a biomarker of CAD. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.