Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions
Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions
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DOI：
10.1016/j.drugalcdep.2006.10.003
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发表时间：
2007-05-11
影响因子：
4.2
通讯作者：
Lynskey, Michael T.
中科院分区：
文献类型：
--
作者：
Agrawal, Arpana;Lynskey, Michael T.
以前的研究已经指出，一个一维的潜在结构的基础标准大麻滥用和依赖。然而，迄今为止，还没有研究探讨性别是否有助于异质性的潜在滥用和依赖结构，此外，在占滥用和依赖的平均分数的差异，跨性别，是否有任何证据的异质性在个人滥用和依赖标准。本研究利用大麻滥用和依赖标准的数据，从一个大的，全国代表性的样本（酒精和相关条件的全国流行病学调查）8172终身大麻使用者调查性别是否有助于异质性的基础结构大麻滥用和依赖，以及在每个单独的标准。分析，所有这些都进行了MPlus，包括因素分析，以及MIMIC和多组模型的维度和性别异质性的检查，分别。结果有利于大麻滥用/依赖的一维结构，如先前的研究所示。我们还确定了两个滥用（法律的和危害）和两个依赖（退出和问题）的标准，这表明显着的性别异质性与滥用标准表现出较高的阈值在女性和男性的依赖标准。我们的结论是，作为DSM-IV大麻滥用和依赖性指标的标准在男性和女性中的作用并不相同，某些标准（例如危险使用）需要进一步完善。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Previous research has noted that a unidimensional latent construct underlies criteria for cannabis abuse and dependence. However, no study to date has explored whether gender contributes to heterogeneity in the latent abuse and dependence construct and furthermore, whether after accounting for differences in the mean scores of abuse and dependence across genders, there is any evidence for heterogeneity in the individual abuse and dependence criteria. The present study utilizes data on criteria for cannabis abuse and dependence from a large, nationally representative sample (National Epidemiological Survey on Alcohol and Related Conditions) of 8172 lifetime cannabis users to investigate whether gender contributes to heterogeneity in the underlying construct of cannabis abuse and dependence, and in each individual criterion as well. Analyses, all of which were conducted in MPlus, included factor analysis, as well as MIMIC and multiple-group models for an examination of dimensionality and gender heterogeneity, respectively. Results favor a unidimensional construct for cannabis abuse/dependence, as seen in prior research. We also identify two abuse (legal and hazard) and two dependence (quit and problems) criteria, which show significant gender heterogeneity with the abuse criteria exhibiting higher thresholds in women and the dependence criteria in men. We conclude that the criteria that serve as indicators of DSM-IV cannabis abuse and dependence do not function identically in men and women and that certain criteria (e.g. hazardous use) require further refinement. (c) 2006 Elsevier Ireland Ltd. All rights reserved.