Motor Responses to Noxious Stimuli Shape Pain Perception in Chronic Pain Patients
Motor Responses to Noxious Stimuli Shape Pain Perception in Chronic Pain Patients
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DOI：
10.1523/eneuro.0290-18.2018
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发表时间：
2018-09
期刊：
影响因子：
3.4
通讯作者：
Henrik Heitmann;E. S. May;L. Tiemann;P. Schmidt;Moritz M. Nickel;Son Ta Dinh;Vanessa D. Hohn;T. Tölle;M. Ploner
中科院分区：
文献类型：
--
作者：
Henrik Heitmann;E. S. May;L. Tiemann;P. Schmidt;Moritz M. Nickel;Son Ta Dinh;Vanessa D. Hohn;T. Tölle;M. Ploner
摘要疼痛具有重要的保护功能，这在很大程度上取决于对伤害性刺激的适当运动反应。这种反应不仅依赖于，而且本身可以塑造疼痛的感知。在慢性疼痛中，感知通常与伤害性刺激脱钩，运动反应不再具有保护性，这表明伤害性刺激，疼痛感知和行为之间的关系可能会改变。我们在这里进行了一个简单的实验，定量评估22名慢性疼痛患者和22名年龄匹配的健康人参与者的伤害性刺激，感知和行为之间的关系。短暂的伤害和触觉刺激施加到参与者的手和参与者进行加速运动反应，并提供刺激的感知评级。多层次调解分析评估的刺激强度，感知评级和反应时间的刺激类型之间的关系。结果显示，一个显着更强的参与运动反应在翻译的伤害性刺激感知比翻译的触觉刺激感知。慢性疼痛患者和健康参与者都发现运动反应对疼痛感知的显著影响。因此，刺激-感知-行为关系似乎至少部分地保留在慢性疼痛患者和运动相关的以及行为干预可能利用这些功能关系来调节疼痛感知。
Abstract Pain serves vital protective functions, which crucially depend on appropriate motor responses to noxious stimuli. Such responses not only depend on but can themselves shape the perception of pain. In chronic pain, perception is often decoupled from noxious stimuli and motor responses are no longer protective, which suggests that the relationships between noxious stimuli, pain perception, and behavior might be changed. We here performed a simple experiment to quantitatively assess the relationships between noxious stimuli, perception and behavior in 22 chronic pain patients and 22 age-matched healthy human participants. Brief noxious and tactile stimuli were applied to the participants’ hands and participants performed speeded motor responses and provided perceptual ratings of the stimuli. Multi-level moderated mediation analyses assessed the relationships between stimulus intensity, perceptual ratings and reaction times for both stimulus types. The results revealed a significantly stronger involvement of motor responses in the translation of noxious stimuli into perception than in the translation of tactile stimuli into perception. This significant influence of motor responses on pain perception was found for both chronic pain patients and healthy participants. Thus, stimulus-perception-behavior relationships appear to be at least partially preserved in chronic pain patients and motor-related as well as behavioral interventions might harness these functional relationships to modulate pain perception.