Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women
Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women
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DOI：
10.1111/j.1530-0277.2002.tb02595.x
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发表时间：
2002-05-01
影响因子：
3.2
通讯作者：
Pfefferbaum, A
中科院分区：
文献类型：
--
作者：
Sullivan, EV;Desmond, JE;Pfefferbaum, A
背景：小脑损伤是酒精中毒的一种伴随疾病，可破坏运动的质量和规律性。是否有证据表明这种功能障碍徘徊在患者与简单的酒精中毒，这是众所周知的影响小脑结构integrity.Methods：我们使用定量措施，以检查组件过程的五个类的运动与区域小脑功能：肢体共济失调（交替手指敲击和变种的手指到鼻子和脚跟到胫骨测试），节奏敲击。眼-手协调跟踪、反映准备和执行时间的定时响应以及姿势稳定性。研究对象为39名戒酒者（13名男性和26名女性）和21名年龄匹配的对照组（9名男性和12名女性）。对于肢体共济失调，相关的措施是轨迹偏离受试者自己的平均运动路径和从起点到终点的旅行速度。结果：重复测量方差分析比较手指到鼻子和脚跟到小腿的运动速度在所有条件下产生显着的相互作用（p < 0.007）;这表明酗酒者在上肢任务中比下肢任务相对较慢。与对照组男性相比，酗酒男性的运动明显较慢，但在所有上肢条件下偏离理想轨迹的程度较低（p < 0.002）。虽然下肢运动轨迹的测量不能区分各组，但站立和步态共济失调的测试可以区分。然而，在定时敲击或正弦tracing.Conclusions：酒精相关的姿势不稳定的戒酒者的功能证据支持假设的损害前上级蚓部的测试组没有差异。改变速度或准确性的权衡，与酗酒者移动速度较慢，以达到相等或甚至更小的轨迹偏差，是小脑半球功能障碍的症状，其特征是审议其他自动运动。
Background: Lesions of the cerebellum, a concomitant of alcoholism, can disrupt quality and regularity of movement. Whether evidence for such dysfunction lingers in patients with uncomplicated alcoholism, which is known to affect cerebellar structural integrity, is controversial.Methods: We used quantitative measures to examine component processes of five classes of movement associated with regional cerebellar function: limb ataxia (alternated finger tapping and variants of the finger-to-nose and heel-to-shin tests), paced tapping. eye-hand coordinated tracing, timed response reflecting preparation and execution time, and postural stability. The subjects examined were 39 abstinent alcoholics (13 men and 26 women) and 21 age-matched controls (9 men and 12 women). For limb ataxia, the dependent measures were the trajectory deviation from the subject's own average movement path and the speed of travel from beginning points to endpoints.Results: Repeated-measures analysis of variance comparing movement speed of finger to nose and heel to shin yielded significant interactions in all conditions (p < 0.007); this indicated that the alcoholics were relatively slower in the upper- than lower-limb tasks. Movements by the alcoholic men were significantly slower but less deviant from an ideal trajectory in all upper-limb conditions than those of the control men (p < 0.002). Although measures of lower-limb movement trajectory did not distinguish the groups, tests of ataxia of stance and gait did. The groups did not differ, however, on tests of timed tapping or sinusoid tracing.Conclusions: Alcohol-related postural instability in abstinent alcoholics is functional evidence supporting the postulated damage to the anterior superior vermis. Altered speed or accuracy trade-offs, with alcoholics moving slower to attain equivalent or even smaller trajectory deviations, are symptomatic of cerebellar hemisphere dysfunction that is characterized by deliberation of otherwise automatic movements.