Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women: The Multi-Ethnic Study of Atherosclerosis-Brief Report.
Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women: The Multi-Ethnic Study of Atherosclerosis-Brief Report.
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DOI：
10.1161/atvbaha.120.315886
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发表时间：
2021-05-05
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影响因子：
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通讯作者：
Delaney JAC
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文献类型：
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作者：
Feinstein MJ;Doyle MF;Stein JH;Sitlani CM;Fohner AE;Huber SA;Landay AL;Heckbert SR;Rice K;Kronmal RA;Hedrick C;Manichaikul A;McNamara C;Rich S;Tracy RP;Olson NC;Psaty BM;Delaney JAC
补充数字内容可在正文中找到。很少有以人群为基础的队列研究调查淋巴系和髓系细胞亚群在心血管疾病发生和进展中的前瞻性关联。这项分析的目的是确定预先指定的髓系和淋巴系细胞亚群与颈总动脉内中膜厚度(IMT)进展的相关性。我们对来自动脉粥样硬化多种族研究的1195名参与者进行了一项前瞻性病例队列研究，这些参与者储存了基线检查中的外周血单核细胞。关键暴露变量是预先指定的淋巴系和髓系免疫细胞亚群，通过多色流式细胞术进行表型分析。主要结果是颈总动脉IMT从基线(试验1)进展到10年(试验5)。非经典单核细胞(CD14dimCD16++)比例较高与10年后IMT的进展显著相关，但经典单核细胞(CD14++CD16−)、CD 4+CD28−T细胞和产生IL-17的辅助性T细胞(IL-17；T辅助细胞)与10年后IMT的显著变化无关。单核细胞亚群与性别之间在IMT进展方面存在显著的交互作用：在性别分层分析中，男性非经典单核细胞与显著的IMT进展相关，经典单核细胞与显著的IMT退化相关，而女性单核细胞亚群与IMT改变无显著关联。非经典单核细胞与颈动脉IMT的进展相关。单核细胞亚群与IMT进展的相关性存在显著的性别差异：对于男性，非经典单核细胞与IMT进展相关，经典单核细胞与IMT进展相关，而对于女性，这些关联为零。
Supplemental Digital Content is available in the text. Few studies of population-based cohorts have investigated prospective associations of lymphoid and myeloid cell subsets in cardiovascular disease onset and progression. The purpose of this analysis was to determine associations of prespecified myeloid and lymphoid lineage cell subsets with common carotid artery intima-media thickness (IMT) progression. We performed a prospective case-cohort study of 1195 participants from the Multi-Ethnic Study of Atherosclerosis who had peripheral blood mononuclear cells stored from the baseline examination. Key exposure variables were prespecified subsets of lymphoid and myeloid lineage immune cells, phenotyped by multicolor flow cytometry. The primary outcome was progression from baseline (Exam 1) to year 10 (Exam 5) in common carotid IMT. Higher proportions of nonclassical monocytes (CD14dimCD16++) were significantly associated with IMT progression over 10 years, but classical monocytes (CD14++CD16−), CD4+CD28− T cells, and T helper cells producing IL-17 (interleukin 17; T helper 17 cells) were not associated with significant changes in IMT over 10 years. There were significant interactions between monocyte subsets and sex with respect to IMT progression: in sex-stratified analyses, nonclassical monocytes were associated with significant IMT progression and classical monocytes were associated with significant IMT regression for men, whereas there were no significant associations of monocyte subsets with IMT change for women. Nonclassical monocytes were associated with progression of carotid IMT. There were significant sex differences in associations of monocyte subsets with IMT progression: for men, nonclassical monocytes were associated with IMT progression and classical monocytes were associated with regression, whereas these associations were null for women.