Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis
Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis
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DOI：
10.1165/rcmb.2004-0304oc
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发表时间：
2005-02-01
影响因子：
6.4
通讯作者：
Losty, PD
中科院分区：
文献类型：
--
作者：
Jesudason, EC;Smith, NP;Losty, PD
来自不同物种的产前气道能够在每个妊娠期自发蠕动收缩。这种平滑肌活动的功能尚不清楚。我们证明，pathesis的胚胎气道起源于一个侧面的起搏器焦点，是刺激的钙依赖性的方式由肺形态发生原成纤维细胞生长因子-10（FGF-10），并出现耦合到肺的生长。气道扩张可能对肺发育至关重要（从而为气道平滑肌提供生理作用），并在已报道的转基因突变肺表型中发挥迄今未预料到的作用。
Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FGF-10), and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiologic role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes.