Short and middle-latency Median Nerve (MN) SEPs recorded by depth electrodes in human pre-SMA and SMA-proper
Short and middle-latency Median Nerve (MN) SEPs recorded by depth electrodes in human pre-SMA and SMA-proper
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DOI：
10.1016/j.clinph.2005.07.022
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发表时间：
2005-11-01
影响因子：
4.7
通讯作者：
Mauguière, F
中科院分区：
文献类型：
--
作者：
Barba, C;Valeriani, M;Mauguière, F
目的：分析 14 例癫痫患者（9 例为 SMA 前患者，3 例为 SMA 正常患者，各 2 例）植入 SMA 立体定向电极记录的正中神经 (MN) SEP 的波形、潜伏期和振幅，以评估该区域产生了哪些短潜伏期和中潜伏期 SEP，以及哪些可能是这些反应的生理相关性。方法：通过长期植入的电极记录短潜伏期和中潜伏期 MN SEP。在 14 名耐药性癫痫患者的额颞叶皮层，特别是额叶内侧区域。 100 ps 的 MN 刺激由手腕处的皮肤电极传递；刺激强度调整为略高于运动阈值。结果：本研究的主要结果是，中潜伏期 SEP 起源于前 SMA，而不是起源于 SMA 本身，如参考记录和双极记录所示。特别是，植入前 SMA 中和额叶外部区域中的相邻接触点之间的离线计算双极迹线显示出位于前 SMA 中最深接触点处的相位反转。相反，植入 SMA 本身和额叶外部区域的相邻接触之间的双极记录显示，植入在区域 6 的更浅表接触处出现反转恢复。最后，我们确认整个 SMA 中没有起源于短潜伏期 MN SEP（特别是 N30）。结论：在运动前区域中，体感输入似乎到达前 SMA 和区域 6，但未到达 SMA 本身。意义：本研究评估没有头皮MN 刺激后的前 100 毫秒内的 SEP 可以在 SMA 中生成。 (c) 2005 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: To analyse waveforms, latencies and amplitudes of Median Nerve (MN) SEPs recorded by stereotactically electrodes implanted in the SMA of 14 epileptic patients (9 in pre-SMA,3 in SMA-proper, 2 in both) in order to evaluate which short and middle-latency SEPs are generated in this area and which could be the physiological relevance of these responses.Methods: Short and middle-latency MN SEPs were recorded by chronically implanted electrodes in the fronto-temporal cortex and in particular in the mesial frontal region of 14 drug-resistant epileptic patients. MN stimulations of 100 ps were delivered by skin electrodes at the wrist; stimulus intensity was adjusted slightly above the motor threshold.Results: The main result of this study is that middle-latency SEPs were originated in pre-SMA but not in SMA-proper as demonstrated by both referential and bipolar recordings. In particular off-line computed bipolar traces between neighbouring contacts implanted in the pre-SMA and in the frontal external regions showed a phase reversal at the deepest contacts located in pre-SMA. Conversely, bipolar recordings between neighbouring contacts implanted in the SMA-proper and in the frontal external regions showed inversion recovery at more superficial contacts, implanted in area 6. Finally, we confirmed that no short-latency MN SEP (and in particular the N30) is originated in the whole SMA.Conclusions: Among premotor areas, somatosensory inputs seem to reach pre-SMA and area 6 but not SMA-proper.Significance: This study assessed that no scalp SEP in the first 100 ms after MN stimulus could be generated in SMA-proper. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.