Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse
Daily injection of insulin attenuated impairment of liver circadian clock oscillation in the streptozotocin-treated diabetic mouse
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DOI：
10.1016/j.febslet.2004.07.036
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发表时间：
2004-08-13
期刊：
影响因子：
3.5
通讯作者：
Shibata, S
中科院分区：
文献类型：
--
作者：
Kuriyama, K;Sasahara, K;Shibata, S
最近的研究表明，链脲佐菌素（STZ）治疗的大鼠和小鼠心脏和肝脏中的时钟基因节律幅度受到抑制，但尚不清楚这种损害是否由于视交叉上核（SCN）功能障碍所致。在stz处理的小鼠肝脏中，mPER2的节律性表达受到抑制，但在SCN和大脑皮层中没有。夜间注射胰岛素可使肝脏中mPer2和mPer2表达节律损伤恢复正常，而白天注射胰岛素则不能。在本研究中，我们证明了胰岛素依赖型糖尿病会损害外周时钟基因及其产物的振荡。胰岛素注射可根据注射时间恢复外周时钟的衰减振荡。(C) 2004年由Elsevier B.V.代表欧洲生化学会联合会出版。
Recent studies have shown a dampened amplitude of clock gene rhythm in the heart and liver of streptozotocin (STZ)-treated rats and mice, however it is unknown whether impairment is due to dysfunction of the suprachiasmatic nucleus (SCN) or not. Rhythmic expression of mPER2 was dampened in the STZ-treated mouse liver but not SCN and cerebral cortex. Injection of insulin could normalize an impairment of mPer2 and mPER2 expression rhythm in the liver, when it was injected at nighttime, but not at daytime. In the present study, we demonstrated that insulin-dependent diabetes impaired oscillation of the peripheral clock gene and its product. Insulin injection can recover dampened oscillation of the peripheral clock depending on its injection time. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.