A Randomized trial of atropine regimens for treatment of moderate amblyopia in children
A Randomized trial of atropine regimens for treatment of moderate amblyopia in children
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DOI：
10.1016/j.ophtha.2004.04.032
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发表时间：
2004-11-01
期刊：
影响因子：
13.7
通讯作者：
Repka, MS
中科院分区：
文献类型：
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作者：
Repka, MS
目的：比较每日阿托品和周末阿托品治疗7岁以下儿童中度弱视的疗效。设计：前瞻性随机多中心临床试验(30个地点)。参与者：168名7岁以下儿童弱视患者，年龄在20/40到20/80之间，伴有斜视、屈光参差或两者兼而有之。干预：随机分为每日服用阿托品或周末服用阿托品4个月。部分应答者继续接受随机治疗，直到没有进一步的改善。主要观察指标：4个月后弱视眼的视力(VA)。结果：从基线到4个月，两组弱视眼的视力平均改善了2.3行。研究结束时弱视视力在(1)至少20/25或(2)优于或等于听力的儿童中，每日组39例(47%)，周末组45例(53%)。随访结束时，每组均有1例患者健眼视力下降2行。两组的立体视力结果相似。结论：周末阿托品对3~7岁儿童中度弱视的改善幅度与每日阿托品相似。(C)2004年，由美国眼科学会提供。
Objective: To compare daily atropine to weekend atropine as prescribed treatments for moderate amblyopia in children younger than 7 years.Design: Prospective, randomized multicenter clinical trial (30 sites).Participants: One hundred sixty-eight children younger than 7 years with amblyopia in the range of 20/40 to 20/80 associated with strabismus, anisometropia, or both.Intervention: Randomization either to daily atropine or to weekend atropine for 4 months. Partial responders were continued on the randomized treatment until no further improvement was noted.Main Outcome Measure: Visual acuity (VA) in the amblyopic eye after 4 months.Results: The improvement in VA of the amblyopic eye from baseline to 4 months averaged 2.3 lines in each group. The VA of the amblyopic eye at study completion was either (1) at least 20/25 or (2) better than or equal to that of the sound eye in 39 children (47%) in the daily group and 45 children (53%) in the weekend group. The VA of the sound eye at the end of follow-up was reduced by 2 lines in one patient in each group. Stereoacuity outcomes were similar in the 2 groups.Conclusions: Weekend atropine provides an improvement in VA of a magnitude similar to that of the improvement provided by daily atropine in treating moderate amblyopia in children 3 to 7 years old. (C) 2004 by the American Academy of Ophthalmology.