Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip
Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip
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DOI：
10.1016/j.bios.2023.115064
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发表时间：
2023-01-19
影响因子：
12.6
通讯作者：
Chen，Pengyu
中科院分区：
文献类型：
--
作者：
Zhou，Lang;Liu，Lunan;Chen，Pengyu
肿瘤微环境中的实时监测提供了对癌症进展的重要见解和对癌症治疗反应的机制理解。然而，临床挑战和重大问题仍然存在于有限的临床组织样本的评估，建立有效的，可控的临床前癌症模型，监测静态与动态标志物，以及从玻璃体肿瘤微环境中获得的见解的翻译系统的调查和理解在临床实践中。本文将回顾最先进的肿瘤芯片策略，并将研究用于肿瘤微环境芯片分析的新兴实时传感和监测平台。将进一步评估传感器与肿瘤芯片平台的集成，以提供肿瘤微环境的时空信息以及相关的挑战。尽管用于原位监测的最佳集成系统仍在发展中，但未来将为快速，全面分析癌症发展开辟新的范例，并为临床医生提供强大的工具来指导癌症的诊断，预后和治疗过程。
Real-time monitoring in the tumor microenvironment provides critical insights of cancer progression and mechanistic understanding of responses to cancer treatments. However, clinical challenges and significant questions remain regarding assessment of limited clinical tissue samples, establishment of validated, controllable pre-clinical cancer models, monitoring of static versus dynamic markers, and the translation of insights gained fromin vitrotumor microenvironments to systematic investigation and understanding in clinical practice. State-of-art tumor-on-a-chip strategies will be reviewed herein, and emerging real-time sensing and monitoring platforms for on-chip analysis of tumor microenvironment will also be examined. The integration of the sensors with tumor-on-a-chip platforms to provide spatiotemporal information of the tumor microenvironment and the associated challenges will be further evaluated. Though optimal integrated systems for in situ monitoring are still in evolution, great promises lie ahead that will open new paradigm for rapid, comprehensive analysis of cancer development and assist clinicians with powerful tools to guide the diagnosis, prognosis and treatment course in cancer.