Illustrating bias due to conditioning on a collider
Illustrating bias due to conditioning on a collider
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DOI：
10.1093/ije/dyp334
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发表时间：
2010-04-01
影响因子：
7.7
通讯作者：
Poole, Charles
中科院分区：
文献类型：
--
作者：
Cole, Stephen R.;Platt, Robert W.;Poole, Charles
对暴露和结果的共同效应进行条件设定可能会导致选择偏差或对撞分层偏差，这一点并不直观。我们提供两个假设的例子来阐述因对撞因子进行条件设定而产生偏差的基本概念。在第一个例子中，发烧是流感和食用受污染的鸡蛋沙拉三明治的共同效应。在第二个例子中，病例状态是一种基因型和一个环境因素的共同效应。在这两个例子中，对共同效应进行条件设定会在两个原本独立的变量之间产生关联；我们将此称为选择偏差。
That conditioning on a common effect of exposure and outcome may cause selection, or collider-stratification, bias is not intuitive. We provide two hypothetical examples to convey concepts underlying bias due to conditioning on a collider. In the first example, fever is a common effect of influenza and consumption of a tainted egg-salad sandwich. In the second example, case-status is a common effect of a genotype and an environmental factor. In both examples, conditioning on the common effect imparts an association between two otherwise independent variables; we call this selection bias.